Molecular structure of SU 5402, CAS Number: 215543-92-3
SU 5402 (CAS 215543-92-3)
See product citations (36)
Alternate Names:
3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid
Application:
SU 5402 is a FGFR-specific tyrosine kinase inhibitor
CAS Number:
215543-92-3
Purity:
≥97%
Molecular Weight:
296.32
Molecular Formula:
C17H16N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU 5402 is a FGFR (fibroblast growth factor receptor)-specific tyrosine kinase inhibitor. Multiple myeloma studies suggest that SU 5402 inhibits FGFR3 phosphorylation in vitro. Research shows that inhibition of FGFR results in the blocking of nodal vesicular parcels (NVPs) secretion and an increase of Ca2+. Additionally, SU 5402 has been observed to inhibit IL-1beta-induced MAPK activity. SU 5402 is an inhibitor of Flg, Flk-1 and PDGFR-beta.
SU 5402 (CAS 215543-92-3) References
- The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. | Skaper, SD., et al. 2000. J Neurochem. 75: 1520-7. PMID: 10987832
- Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. | Mahboobi, S., et al. 2002. J Med Chem. 45: 1002-18. PMID: 11855980
- Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway. | Yamashita, T., et al. 2002. J Biol Chem. 277: 28265-70. PMID: 12032146
- Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways. | Noble, PJ., et al. 2003. Am J Physiol Gastrointest Liver Physiol. 284: G75-84. PMID: 12488236
- Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. | Paterson, JL., et al. 2004. Br J Haematol. 124: 595-603. PMID: 14871245
- FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. | Tanaka, Y., et al. 2005. Nature. 435: 172-7. PMID: 15889083
- IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line. | Petersen, LG., et al. 2006. Diabetologia. 49: 1864-75. PMID: 16718462
- FGFs, Wnts and BMPs mediate induction of VEGFR-2 (Quek-1) expression during avian somite development. | Nimmagadda, S., et al. 2007. Dev Biol. 305: 421-9. PMID: 17425953
- Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes. | Widberg, CH., et al. 2009. Am J Physiol Endocrinol Metab. 296: E121-31. PMID: 18940940
- Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue. | Kachel, P., et al. 2015. BMC Cancer. 15: 140. PMID: 25880801
- Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis. | Bray, LJ., et al. 2015. Biomaterials. 53: 609-20. PMID: 25890757
- Rapid, Directed Differentiation of Retinal Pigment Epithelial Cells from Human Embryonic or Induced Pluripotent Stem Cells. | Foltz, LP. and Clegg, DO. 2017. J Vis Exp.. PMID: 29155780
- FGF Signalling in the Self-Renewal of Colon Cancer Organoids. | Otte, J., et al. 2019. Sci Rep. 9: 17365. PMID: 31758153
Inhibitor of:
1700001F09Rik, 2410066E13Rik, Angiogenesis, ASCL5, Axonin-1, BC056474, BC080695, bFGF, C1orf187, Chox10, Cnpy1, DMRTA1, EG668339, EG668419, EGFL3, FGF-2, FGF-8F, FGF-BP, FGF-BP3, FGFR, FHL-5, FIBP, Fibroblast Growth Factor (FGF), Flg, Flk-1, GFR-1, GFRαL, GFRA (GDNF family receptor alpha), IRX1, ISOC1, LBX2, LOC100041222, LOC100041358, LOC342541, LOC440338, LOC728149, LOC728896, LOC729878, MAB21L2, MATH-2, MESP1, N-twist, Nkx-6.3, OOEP, OTP, PDGFR-beta, PDZK7, Pecanex 2, PTN, Ripply1, robo1, robo2, SBEM, SEMA3C, Sidekick-2, Slit2, Sox-12, SPATA1, Spitz, TGaseZ, TMEFF2, TMEM46, TPBG, UNC5H2, UNCX, VAX2, Vmn2r109, WDR35, ZNF135, ZNF230, ZNF234, ZNF253, ZNF257, ZNF443, ZNF468, and ZNF565.Activator of:
β-FR, Bek, brachyury, chordin, Dab2, DCC, Delta-4, ephrin-A4, FAM20A, FGF-1, Flg, PRAT4B_Cnpy4, RYK, Scleraxis, SSEA-4, TBX15, and tinman.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU 5402, 1 mg | sc-204308 | 1 mg | $62.00 | |||
SU 5402, 5 mg | sc-204308A | 5 mg | $96.00 |