FBXW24 Activators
FBXW24, a crucial component in cellular regulatory networks, plays a pivotal role in protein degradation and cellular homeostasis. Functionally, FBXW24 operates as a substrate recognition subunit within the Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex, targeting specific proteins for ubiquitin-mediated degradation. Its activation is intricately tied to various biochemical and cellular pathways, with a network of chemicals modulating its expression indirectly. The target protein FBXW24 exhibits a multifaceted function, primarily involved in the regulation of cellular responses to environmental stimuli, oxidative stress, and growth signals. As a substrate recognition module, FBXW24 facilitates the targeted degradation of proteins, influencing diverse cellular processes, such as antioxidant defenses, metabolic adaptation, immune homeostasis, and cellular growth. This versatile functionality underscores its significance in maintaining cellular equilibrium under varying conditions.
Activation of FBXW24 is intricately linked to specific signaling pathways, with a diverse array of chemicals influencing its expression. Sulforaphane, for instance, enhances FBXW24 expression by modulating the Keap1-Nrf2 pathway, reinforcing antioxidant defenses. Resveratrol indirectly activates FBXW24 through the SIRT1 pathway, connecting stress response and longevity with FBXW24-mediated proteolysis. These examples demonstrate how various chemicals influence distinct pathways, ultimately converging on FBXW24 activation. Furthermore, chemicals like quercetin, curcumin, luteolin, and genistein exert their effects by modulating AMPK, NF-κB, PI3K-Akt, and ERK-MAPK pathways, respectively. These pathways serve as conduits through which cellular energy sensing, inflammatory responses, growth factor signaling, and extracellular stimuli influence FBXW24 expression. The indirect activation of FBXW24 by these chemicals establishes critical connections between diverse cellular processes and FBXW24-mediated protein degradation. In summary, FBXW24 emerges as a central player in cellular homeostasis, orchestrating the degradation of specific proteins to maintain equilibrium under various conditions. Its activation is finely tuned by a network of chemicals, each influencing distinct pathways that converge on FBXW24 expression. Understanding these intricate mechanisms provides insights into the regulatory dynamics of FBXW24 and its pivotal role in cellular adaptation and response to environmental cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates FBXW24 by modulating the Keap1-Nrf2 pathway. Acting as an indirect activator, it enhances the degradation of Keap1, allowing Nrf2 to translocate and induce FBXW24 expression. This activation reinforces cellular antioxidant defenses through FBXW24-mediated degradation of specific targets, promoting cellular resilience. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, an indirect activator of FBXW24, influences the SIRT1 pathway. By enhancing SIRT1 activity, it indirectly up-regulates FBXW24 expression. This activation contributes to cellular homeostasis by regulating protein turnover, connecting the SIRT1 pathway with FBXW24-mediated proteolysis and influencing various cellular processes involved in stress response and longevity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin acts as an indirect activator by modulating the AMPK pathway. By activating AMPK, it triggers a cascade of events leading to FBXW24 up-regulation. This activation provides a link between cellular energy sensing and FBXW24-mediated protein degradation, promoting metabolic adaptation and contributing to the maintenance of cellular homeostasis under varying energy conditions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, an indirect activator of FBXW24, influences the NF-κB pathway. By inhibiting NF-κB signaling, it indirectly promotes FBXW24 expression. This activation establishes a connection between inflammatory responses and FBXW24-mediated protein degradation, contributing to the regulation of immune homeostasis and cellular adaptation to inflammatory stimuli. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin, an indirect activator, influences the PI3K-Akt pathway. By modulating PI3K-Akt signaling, it up-regulates FBXW24 expression. This activation establishes a link between growth factor signaling and FBXW24-mediated protein degradation, contributing to the regulation of cellular growth and survival in response to extracellular cues. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein acts as an indirect activator by modulating the ERK-MAPK pathway. By influencing ERK-MAPK signaling, it triggers FBXW24 up-regulation. This activation connects extracellular stimuli with FBXW24-mediated protein degradation, contributing to the regulation of cell proliferation and differentiation in response to growth factor signaling. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG serves as an indirect activator by influencing the mTOR pathway. By inhibiting mTOR signaling, it up-regulates FBXW24 expression. This activation establishes a link between nutrient sensing and FBXW24-mediated protein degradation, contributing to the regulation of cellular metabolism and adaptation to nutrient availability. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $46.00 $130.00 | 21 | |
Thymoquinone, an indirect activator, influences the Wnt/β-catenin pathway. By modulating Wnt signaling, it up-regulates FBXW24 expression. This activation establishes a connection between developmental signaling pathways and FBXW24-mediated protein degradation, contributing to the regulation of cellular differentiation and tissue homeostasis in response to Wnt signals. | ||||||
Pterostilbene, Pterocarpus marsupium | 537-42-8 | sc-203223 sc-203223A | 10 mg 100 mg | $207.00 $1173.00 | ||
Pterostilbene acts as an indirect activator by modulating the FOXO pathway. By enhancing FOXO activity, it triggers FBXW24 up-regulation. This activation establishes a link between oxidative stress and FBXW24-mediated protein degradation, contributing to the regulation of cellular response to oxidative challenges and the maintenance of redox balance. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic Acid, an indirect activator, influences the HIF-1α pathway. By modulating HIF-1α signaling, it up-regulates FBXW24 expression. This activation establishes a connection between oxygen sensing and FBXW24-mediated protein degradation, contributing to the regulation of cellular response to hypoxic conditions and the maintenance of oxygen homeostasis. | ||||||