Molecular structure of Pterostilbene, Pterocarpus marsupium, CAS Number: 537-42-8
Pterostilbene, Pterocarpus marsupium (CAS 537-42-8)
Application:
Pterostilbene, Pterocarpus marsupium is a Cox-1 and Cox-2 inhibitor
CAS Number:
537-42-8
Purity:
≥98%
Molecular Weight:
256.3
Molecular Formula:
C16H16O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pterostilbene, a compound originally derived from Pterocarpus marsupium, has been shown to be a free radical scavenger as well as a moderate inhibitor of Cox-1 (IC50 = 19.8 µM) and Cox-2 (IC50 = 83.9 µM). Pterostilbene has also been reported to induce PPARα (peroxisome proliferator-activated receptor α), which causes a decrease in lipid and glucose concentration. Additional experiments have shown that Pterostilbene also suppresses Azoxymethane (sc-252398) induced formation of aberrant crypt foci in male rats.
Pterostilbene, Pterocarpus marsupium (CAS 537-42-8) References
- Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. | Rimando, AM., et al. 2002. J Agric Food Chem. 50: 3453-7. PMID: 12033810
- Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. | Rimando, AM., et al. 2005. J Agric Food Chem. 53: 3403-7. PMID: 15853379
- Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. | Suh, N., et al. 2007. Clin Cancer Res. 13: 350-5. PMID: 17200374
- Pterostilbene attenuates acute kidney injury in septic mice. | Xia, Y., et al. 2018. Exp Ther Med. 15: 3551-3555. PMID: 29545882
- Pterostilbene Ameliorates DSS-Induced Intestinal Epithelial Barrier Loss in Mice via Suppression of the NF-κB-Mediated MLCK-MLC Signaling Pathway. | Wang, J., et al. 2021. J Agric Food Chem. 69: 3871-3878. PMID: 33759516
- Gastrointestinal biotransformation and tissue distribution of pterostilbene after long-term dietary administration in mice. | Sun, Y., et al. 2022. Food Chem. 372: 131213. PMID: 34638060
- Based on Network Pharmacology and Gut Microbiota Analysis to Investigate the Mechanism of the Laxative Effect of Pterostilbene on Loperamide-Induced Slow Transit Constipation in Mice. | Yao, Z., et al. 2022. Front Pharmacol. 13: 913420. PMID: 35652049
- Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet. | Gu, W., et al. 2022. Kidney Blood Press Res. 47: 514-522. PMID: 35717941
- Pterostilbene accelerates wound healing response in diabetic mice through Nrf2 regulation. | Ganesh, GV. and Ramkumar, KM. 2023. Mol Immunol. 164: 17-27. PMID: 37926050
- Antihyperglycemic activity of phenolics from Pterocarpus marsupium. | Manickam, M., et al. 1997. J Nat Prod. 60: 609-10. PMID: 9214733
Inhibitor of:
c-Jun, C5orf58, Cox-2, CYP1A1, GRB2, IRF-7, LOC440233, RAP1, Rev-erbα, SA-1, and USF-1.Activator of:
ASCC2, Centrin-2, COX8b, DDAH I, DNA pol γ2, DnaJB3, FBXW24, Humanin, LOC100041273, MacroH2A2, MBPH, NDUFAF6, NDUFB11, NMNAT-3, NRK1, Oas1f, PARS2, PBEF, PIF1, PPAN, RGS13, RTCD1, SART-1, SCO2, SerpinA3j, SIRT4, SIRT5, SUV3, TFIIH p44, V3R 3, VEGI, VPS33B, X11, and ZFP319.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pterostilbene, Pterocarpus marsupium, 10 mg | sc-203223 | 10 mg | $207.00 | |||
Pterostilbene, Pterocarpus marsupium, 100 mg | sc-203223A | 100 mg | $1173.00 |