FANK1 Inhibitors
Chemical inhibitors of FANK1 can achieve functional inhibition through various mechanisms by targeting signaling pathways that FANK1 is known to be part of. Staurosporine, a broad-spectrum protein kinase inhibitor, can hinder FANK1's kinase activity by preventing the phosphorylation of its substrates, which is a crucial step for its function. Similarly, 5-Iodotubercidin, as an adenosine kinase inhibitor, can block the phosphorylation of adenosine, potentially disrupting FANK1. LY294002 and Wortmannin, both PI3K inhibitors, can suppress the PI3K/Akt signaling pathway. PD98059 and U0126, which target MEK within the MAP kinase pathway, can prevent the activation of FANK1.
Moreover, SP600125 acts as a JNK inhibitor and can functionally inhibit FANK1. SB203580, by inhibiting p38 MAP kinase, can also interfere with FANK1 activity. Rapamycin, an inhibitor of mTOR, can suppress FANK1 function. PP2, which inhibits Src family kinases, would disrupt Src kinase signaling, subsequently affecting FANK1 activity. Lastly, Gefitinib, which specifically inhibits the EGFR tyrosine kinase, would impede FANK1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. FANK1 is a kinase, and the inhibition of its kinase activity by staurosporine would prevent FANK1 from phosphorylating its substrates, thus functionally inhibiting its activity. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $153.00 $464.00 | 20 | |
5-Iodotubercidin is an adenosine kinase inhibitor that could inhibit FANK1 by preventing the phosphorylation of adenosine, which could be necessary for FANK1's kinase activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a protein kinase A inhibitor. By inhibiting protein kinase A, it could reduce phosphorylation levels within the cell, potentially affecting FANK1's activity if FANK1's function is contingent on a phosphorylation cascade involving protein kinase A. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is involved in the Akt signaling pathway, if FANK1's activity is regulated by Akt phosphorylation, LY294002 would inhibit this signaling pathway, thereby inhibiting FANK1 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor, functioning similarly to LY294002, and would inhibit FANK1 by disrupting the PI3K/Akt signaling pathway, if FANK1 is regulated by this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of the MAP kinase pathway specifically MEK. If FANK1's activity is regulated downstream of the MEK/ERK pathway, this inhibitor would prevent FANK1 activation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. If FANK1 is part of a signaling pathway that involves JNK, its inhibition would result in the functional inhibition of FANK1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor, and would functionally inhibit FANK1 if FANK1 is regulated by p38 MAP kinase signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. If FANK1's function is downstream of mTOR signaling, the inhibition of mTOR by rapamycin would lead to functional inhibition of FANK1. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor. If FANK1 activity requires Src kinase signaling, PP2 would inhibit this signaling and thereby inhibit FANK1 function. | ||||||