FAM71B Activators
FAM71B Activators are a class of chemical compounds that enhance. Given the nature of FAM71B's specific pathways and the absence of direct activators, the following is a logical analysis based on the chemical's known actions within cellular signaling pathways that could plausibly interface with proteins such as FAM71B.
Forskolin is known for its ability to activate adenylate cyclase, thereby increasing intracellular cAMP levels. The rise in cAMP enhances PKA activity, which is a key regulator of phosphorylation within the cell. If FAM71B is a substrate for PKA or is involved in pathways regulated by cAMP, its functional activity would be enhanced by this increase in PKA-mediated phosphorylation. Phorbol 12-myristate 13-acetate (PMA) functions by activating PKC, which phosphorylates a broad range of cellular targets. If FAM71B is among the substrates of PKC or is part of a pathway affected by PKC activation, then PMA would directly enhance its functional state through phosphorylation. EGF, upon binding to its receptor, initiates signaling cascades such as the MAPK/ERK pathway, leading to protein phosphorylation events that govern cell growth and differentiation. If FAM71B is integrated within this pathway or modulated by it, EGF engagement would enhance its activity. In a similar vein, insulin activates the PI3K/AKT/mTOR pathway, crucial for cell survival and metabolism. Should FAM71B interact with this signaling route or be modulated by any of its constituents, its functional activity would be enhanced by insulin's action. Ionomycin and A23187, both calcium ionophores, increase intracellular calcium, which is a secondary messenger in various signaling pathways. If FAM71B is calcium-sensitive or regulated by calcium-dependent enzymes, its activity can be enhanced by these ionophores.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in numerous signaling pathways that regulate protein function through phosphorylation. PKC activation can lead to the phosphorylation and functional enhancement of FAM71B if it is a substrate for PKC. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to its receptor, triggering a cascade that can activate the PI3K/AKT/mTOR pathway, which is involved in cell survival and metabolism. FAM71B could be enhanced if it interacts with components of this pathway or is subject to regulation by proteins in the pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent proteins and pathways. Increased calcium can enhance the activity of calcium/calmodulin-dependent protein kinases, potentially affecting FAM71B if it is a substrate. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, which can lead to increased phosphorylation levels on proteins. By inhibiting phosphatases, FAM71B's phosphorylation state and activity could be enhanced if it is regulated by tyrosine phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Like ionomycin, A23187 is a calcium ionophore that elevates intracellular calcium levels, potentially enhancing the activity of proteins that are regulated by calcium signaling, which may include FAM71B. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that leads to the activation of adenylate cyclase and increases cAMP levels. Similar to forskolin, it can enhance the activity of PKA, potentially influencing the phosphorylation and activity of FAM71B. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA. By activating PKA, db-cAMP can potentiate the phosphorylation of substrates potentially including FAM71B, enhancing its functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of serine/threonine protein phosphatases such as PP1 and PP2A, leading to increased phosphorylation of proteins. This could indirectly enhance the phosphorylation state and activity of FAM71B if it is subject to serine/threonine phosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin acts as a protein synthesis inhibitor, but it also activates stress-activated protein kinases like JNK and p38 MAPK. Through the activation of these kinases, FAM71B could be functionally enhanced if it is a downstream target. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K, which paradoxically can lead to feedback activation of certain signaling pathways. If FAM71B is involved in pathways downstream of PI3K, its activity could be indirectly enhanced by the disruption of normal PI3K signaling. | ||||||