FAM108B1 Activators
Forskolin is a well-known lab reagent that functions by stimulating adenylyl cyclase, an enzyme that converts ATP to cyclic AMP (cAMP) in the cell. Elevated levels of cAMP activate protein kinase A (PKA), a critical regulator of numerous biological processes, including the phosphorylation of various proteins. If FAM108B1 were downstream of a PKA-regulated pathway, forskolin could indirectly enhance its activity by increasing cAMP concentrations. Ionomycin, a calcium ionophore, raises intracellular calcium levels, which is a universal second messenger in cells. This increase in calcium can activate a suite of calcium-dependent kinases, which may in turn regulate proteins such as FAM108B1 if it is sensitive to calcium-mediated signaling.
Phorbol 12-myristate 13-acetate (PMA) is another activator which mimics diacylglycerol (DAG) and robustly activates protein kinase C (PKC). PKC phosphorylates serine and threonine amino acid residues on various target proteins. If FAM108B1 were a substrate of PKC or involved in a PKC-regulated pathway, PMA could serve as an indirect activator. Compounds like 5-Azacytidine and Trichostatin A work epigenetically to modulate gene expression. 5-Azacytidine inhibits DNA methyltransferases, potentially causing demethylation of gene promoters and reactivation of silenced genes. If the FAM108B1 gene is epigenetically regulated via methylation, 5-Azacytidine could upregulate its expression. Trichostatin A, on the other hand, inhibits histone deacetylases, leading to a more acetylated and transcriptionally active chromatin state, which could also result in the increased expression of FAM108B1. Retinoic Acid acts as a ligand for nuclear receptors, which when bound, can alter the expression of genes, including potentially those involved in the regulation of FAM108B1. If FAM108B1 is under the control of retinoid-responsive elements, Retinoic Acid could have an indirect activating effect.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin, a calcium ionophore, raises intracellular calcium levels, which can activate calcium/calmodulin-dependent protein kinases. These kinases may indirectly modulate FAM108B1 activity if it is calcium-sensitive. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates serine and threonine residues on various proteins. If FAM108B1 is regulated by PKC-mediated phosphorylation, PMA would indirectly increase its activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, potentially causing demethylation and activation of certain genes. If FAM108B1 expression is epigenetically silenced, 5-Azacytidine could indirectly upregulate its production. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases, leading to a more acetylated and open chromatin structure, which can enhance gene expression. This could increase FAM108B1 levels if it affects genes encoding this protein or its regulators. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid acts as a ligand for nuclear receptors, altering gene expression. If FAM108B1 or its regulatory proteins are influenced by retinoid-responsive elements, Retinoic Acid can indirectly modulate its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 selectively inhibits p38 MAP kinase. If FAM108B1 activity is modulated via the p38 MAPK pathway, this inhibitor could indirectly affect its phosphorylation state and activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K. PI3K signaling affects numerous downstream proteins, including AKT. If FAM108B1 is part of the PI3K/AKT pathway, LY294002 could indirectly alter its activity by modulating the pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits MEK, which is upstream of ERK in the MAPK pathway. If the activity of FAM108B1 is regulated by the MAPK pathway, PD98059 could have an indirect role in modulating its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is a central regulator of cell growth and metabolism. If FAM108B1 function is connected to mTOR signaling, Rapamycin could have an indirect impact on its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates the NF-κB pathway and has been shown to affect the transcription of various genes. If FAM108B1 is regulated by NF-κB or related pathways, Curcumin could indirectly influence its activity. | ||||||