FAAP Inhibitors
FAAP inhibitors function primarily by influencing signaling pathways that the protein is directly involved in. For instance, curcumin and resveratrol are polyphenols that can inhibit NF-κB and STAT3 signaling, respectively. Given that FAAP is involved in the FA pathway that is connected to NF-κB signaling and affects DNA repair processes that are linked to the STAT3 signaling pathway, the inhibition of these pathways by curcumin and resveratrol can lead to a decrease in FAAP functional activity. Similarly, JQ1 is a BET bromodomain inhibitor that can decrease BRD4 activity. As BRD4 is connected to the DNA repair processes in which FAAP is involved, the reduction of BRD4 activity by JQ1 can indirectly lead to the inhibition ofFAAP's functional activity. In addition, quercetin is a flavonoid that can inhibit PI3K/Akt signaling, and LY294002 is a specific inhibitor of PI3Ks. Since FAAP is involved in DNA repair processes that are connected to the PI3K/Akt signaling pathway, the inhibition of this pathway by these compounds can lead to the inhibition of FAAP's functional activity.
Other FAAP inhibitors function by targeting MAPK-related signaling pathways. PD98059, SB203580, and SP600125 are specific inhibitors of MAPKs, p38 MAPK, and JNK, respectively. Given that FAAP is involved in DNA repair processes that are connected to these signaling pathways, their inhibition by these compounds can lead to the inhibition of FAAP's functional activity. Moreover, U0126, ZM336372, and PD0325901 are specific inhibitors of MEK1/2 and RAF1, respectively. Since FAAP is involved in DNA repair processes that are connected to these signaling pathways, the inhibition of these pathways by these compounds can lead to the inhibition of FAAP's functional activity. Thus, the aforementioned compounds inhibit FAAP through a variety of mechanisms, all of which involve the inhibition of signaling pathways and processes that FAAP is directly involved in.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenol that can inhibit NF-κB signaling. FAAP is involved in the FA pathway that is connected to NF-κB signaling, and inhibition of NF-κB signaling by curcumin can lead to a decrease in FAAP functional activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol that can suppress the STAT3 signaling pathway. Since FAAP affects DNA repair processes that are linked to the STAT3 signaling pathway, the suppression of this pathway by resveratrol can lead to the inhibition of FAAP's functional activity. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that can decrease BRD4 activity. As BRD4 is connected to the DNA repair processes in which FAAP is involved, the reduction of BRD4 activity by JQ1 can indirectly lead to the inhibition of FAAP's functional activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can inhibit PI3K/Akt signaling. Given that FAAP is involved in DNA repair processes that are connected to the PI3K/Akt signaling pathway, the inhibition of this pathway by quercetin can lead to the inhibition of FAAP's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3Ks. Since FAAP is involved in DNA repair processes that are connected to the PI3K signaling pathway, the inhibition of this pathway by LY294002 can lead to the inhibition of FAAP's functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of MAPKs. Given that FAAP is involved in DNA repair processes that are connected to the MAPK signaling pathway, the inhibition of this pathway by PD98059 can lead to the inhibition of FAAP's functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Since FAAP is involved in DNA repair processes that are connected to the p38 MAPK signaling pathway, the inhibition of this pathway by SB203580 can lead to the inhibition of FAAP's functional activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a specific inhibitor of JNK. Given that FAAP is involved in DNA repair processes that are connected to the JNK signaling pathway, the inhibition of this pathway by SP600125 can lead to the inhibition of FAAP's functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a specific inhibitor of PI3Ks. Since FAAP is involved in DNA repair processes that are connected to the PI3K signaling pathway, the inhibition of this pathway by Wortmannin can lead to the inhibition of FAAP's functional activity. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $47.00 | 2 | |
ZM336372 is a specific inhibitor of RAF1. Since FAAP is involved in DNA repair processes that are connected to the RAF1 signaling pathway, the inhibition of this pathway by ZM336372 can lead to the inhibition of FAAP's functional activity. | ||||||