FAAP100 Antibody (C-11): sc-393052
- FAAP100 Antibody (C-11) is a mouse monoclonal IgG2b κ FAAP100 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 313-342 within an internal region of FAAP100 of mouse origin
- FAAP100 Antibody (C-11) is recommended for detection of FAAP100 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-FAAP100 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FAAP100 Antibody (C-11) for WB applications. These reagents are now offered in bundles with FAAP100 Antibody (C-11) (see ordering information below).
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FAAP100 Antibody (C-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects FAAP100 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FAAP100 (C-11) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FAAP100, also known as fanconi anemia-associated protein of 100 kDa or C17orf70, is an 881 amino acid protein that plays a crucial role in the fanconi anemia (FA) core complex, which includes FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, and FAAP24. FAAP100 maintains stability of the FA core complex and facilitates FANCD2 monoubiquitination. Nuclear localization of FAAP100 enables complex formation with FANCB and FANCL, essential for DNA repair pathway function. FAAP100 repression leads to chromosomal instability and increased sensitivity to DNA cross-linking agents, highlighting FAAP100′s importance in maintaining genomic integrity. FAAP100 gene is located on human chromosome 17q25.3 and exists in three alternatively spliced isoforms, underscoring regulatory complexity in FAAP100 function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FAAP100 Antibody (C-11) References:
- A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. | Meetei, AR., et al. 2003. Mol Cell Biol. 23: 3417-26. PMID: 12724401
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. | Zody, MC., et al. 2006. Nature. 440: 1045-9. PMID: 16625196
- FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. | Ling, C., et al. 2007. EMBO J. 26: 2104-14. PMID: 17396147
- FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA. | Ali, AM., et al. 2009. Mutat Res. 668: 20-6. PMID: 19379763
- Identification and characterization of mutations in FANCL gene: a second case of Fanconi anemia belonging to FA-L complementation group. | Ali, AM., et al. 2009. Hum Mutat. 30: E761-70. PMID: 19405097
- Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. | Thompson, LH. and Hinz, JM. 2009. Mutat Res. 668: 54-72. PMID: 19622404
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FAAP100 Antibody (C-11) | sc-393052 | 200 µg/ml | $322.00 | |||
FAAP100 Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-523786 | 200 µg Ab, 40 µg BP | $361.00 | |||
FAAP100 Antibody (C-11): m-IgG2b BP-HRP Bundle | sc-549139 | 200 µg Ab; 10 µg BP | $361.00 | |||
FAAP100 Antibody (C-11) AC | sc-393052 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FAAP100 Antibody (C-11) HRP | sc-393052 HRP | 200 µg/ml | $322.00 | |||
FAAP100 Antibody (C-11) FITC | sc-393052 FITC | 200 µg/ml | $336.00 | |||
FAAP100 Antibody (C-11) PE | sc-393052 PE | 200 µg/ml | $349.00 | |||
FAAP100 Antibody (C-11) Alexa Fluor® 488 | sc-393052 AF488 | 200 µg/ml | $364.00 | |||
FAAP100 Antibody (C-11) Alexa Fluor® 546 | sc-393052 AF546 | 200 µg/ml | $364.00 | |||
FAAP100 Antibody (C-11) Alexa Fluor® 594 | sc-393052 AF594 | 200 µg/ml | $364.00 | |||
FAAP100 Antibody (C-11) Alexa Fluor® 647 | sc-393052 AF647 | 200 µg/ml | $364.00 | |||
FAAP100 Antibody (C-11) Alexa Fluor® 680 | sc-393052 AF680 | 200 µg/ml | $364.00 | |||
FAAP100 Antibody (C-11) Alexa Fluor® 790 | sc-393052 AF790 | 200 µg/ml | $364.00 | |||
FAAP100 (C-11) Neutralizing Peptide | sc-393052 P | 100 µg/0.5 ml | $69.00 |