EphB1 Activators
EphB1 Activators encompass a broad category of chemicals that, while not directly interacting with the EphB1 receptor, can indirectly influence its activation state through modulation of various cellular pathways and processes. This indirect activation may occur through the enhancement of pathways that contribute to the biological outcomes dictated by EphB1 signaling or by modulating the cellular environment to favor EphB1 activity.
These activators work by a myriad of mechanisms, such as altering kinase activity, gene expression, or intracellular messenger levels, which in turn affects the EphB1 signaling cascade. For example, agents that increase intracellular cAMP levels can indirectly promote EphB1 activity by activating protein kinase A, which may then phosphorylate proteins that participate in EphB1 signaling. Similarly, chemicals that modulate gene expression, such as Retinoic Acid, may lead to increased levels of EphB1 receptors and their ligands, thereby potentiating the activation of EphB1. Each activator's interaction with cellular signaling reflects the complex and interconnected nature of intracellular signaling pathways, where changes in one part of the network can reverberate through to others, including those involving EphB1. This results in the modulation of EphB1-mediated cell adhesion, migration, and other functions that are essential for proper cellular communication and organization.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor known to activate stress-activated protein kinases, leading to the activation of c-Jun N-terminal kinase (JNK). Activation of JNK has been linked to the enhancement of EphB1 signaling by promoting the assembly of signaling complexes that facilitate the forward signaling of EphB1, thereby promoting cellular responses that are typical of EphB1 activation, such as cell repulsion. | ||||||
(R)-(−)-Phenylephrine hydrochloride | 61-76-7 | sc-203677 sc-203677A | 100 mg 5 g | $49.00 $65.00 | 1 | |
Phenylephrine is an α1-adrenergic receptor agonist that can increase intracellular calcium levels, which in turn could modulate the kinase activity within the EphB1 signaling cascade. Increased intracellular calcium has been associated with the activation of several signal transduction pathways that can converge on and activate EphB1, leading to its downstream effects on cell morphology and motility. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid is known to modulate gene expression through its nuclear receptors. It can upregulate the expression of Eph receptors and ephrin ligands, thereby potentially increasing EphB1 activity by enhancing the expression of both the receptor and its ligands within the cellular environment, which is critical for the receptor's forward and reverse signaling functions. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, can activate protein kinase A (PKA). PKA has been shown to phosphorylate substrates that could modulate EphB1 signaling, potentially enhancing EphB1 forward signaling by promoting receptor-ligand interactions or the assembly of signaling complexes involving EphB1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylyl cyclase activator, increasing cAMP levels within cells. Elevated cAMP can activate PKA, which in turn can phosphorylate substrates involved in the EphB1 signaling cascade, leading to enhanced EphB1 activity and downstream signaling responsible for changes in cellular morphology and movement. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins that are part of the EphB1 signaling complex, thereby potentially enhancing the activation and signaling efficiency of EphB1. This can manifest in the form of increased cell-cell repulsion and axon guidance, which are functions associated with EphB1 activity. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation but can also modulate other signaling pathways. By influencing the NF-κB pathway, BAY 11-7082 may indirectly lead to the upregulation of EphB1 expression or the sensitization of the EphB1 signaling pathway, as NF-κB can act as a transcriptional regulator for various molecules, including those involved in the EphB1 signaling axis. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that can significantly increase intracellular calcium concentrations. Elevated calcium levels can trigger secondary signaling events that promote the activation of EphB1, as calcium signaling plays a crucial role in the regulation of Eph receptor phosphorylation and the formation of receptor clusters that are essential for signal transduction. | ||||||
BML-277 | 516480-79-8 | sc-200700 sc-200700A | 10 mg 50 mg | $129.00 $482.00 | 2 | |
BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor that may affect cell cycle checkpoints and DNA damage response pathways. By modifying these pathways, BML-277 can influence the cellular context in which EphB1 operates, potentially leading to enhanced EphB1 signaling in scenarios where cell adhesion and migration are regulated by EphB1. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
nhibition of GSK-3 can stabilize β-catenin, which can lead to the transcriptional activation of EphB1 and its ligands. By increasing EphB1 expression and promoting receptor-ligand interaction, this compound can enhance EphB1 activation and its downstream signaling that dictates cell positioning and tissue architecture. | ||||||