(R)-(-)-Phenylephrine hydrochloride CAS: 61-76-7
MF: C9H13NO2 HCl
MW: 203.67
An α1-adrenoceptor agonist.

(R)-(-)-Phenylephrine hydrochloride (CAS 61-76-7)

(R)-(-)-Phenylephrine hydrochloride | CAS 61-76-7 is rated 5.0 out of 5 by 1.
  • y_2020, m_7, d_12, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203677, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 166ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
Application: (R)-(−)-Phenylephrine hydrochloride is an α1-adrenoceptor agonist
CAS Number: 61-76-7
Molecular Weight: 203.67
Molecular Formula: C9H13NO2 HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonist that promotes hypertrophic growth in the ventricular myocytes, and activates several MAPK signaling pathways. (R)-(-)-Phenylephrine hydrochloride is an activator of α1A-AR, α1D-AR and α1B-AR.


References

1. Minneman, K.P., et al. 1994. Mol. Pharmacol. 46: 929-936. PMID: 7969082
2. Ford, A.P., et al. 1997. Br. J. Pharmacol. 121: 1127-1135. PMID: 9249248
3. Lazou, A., et al. 1998. Biochem. J. 332: 459-465. PMID: 9601075
4. Hattori, Y. and Kanno, M. 1998. Life Sci. 62: 1449-1453. PMID: 9585117
5. Eckert, R.E., et al. 2000. Urol. Res. 28: 122-127. PMID: 10850635
6. Morton, J.S., et al. 2007. Br. J. Pharmacol. 150: 112-120. PMID: 17115072

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM), DMSO (100 mM), alcohol, methanol, and ethanol (41 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
143-145° C (lit.)
Boiling Point :
341.1° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Optical Activity :
α20/D -43.9°, c = 2 in water; α20/D -51.5°, c = 2 in ethanol; α20/D -45.5°±1.5°, c = 1 in water
IC50 :
Adrenergic receptor α-2: IC50 = 78 nM (rat); Adrenergic receptor α-1: IC50 = 2 µM (rat); Serotonin 2a receptor: EC5050 = 19.26 µM (rat); MOR-1: EC5050 = 92.43 µM (human)
Ki Data :
Adrenergic receptor α-2: Ki= 270 nM (rat); Adrenergic receptor α-2: Ki= 390 nM (human); Adrenergic receptor α-1: Ki= 6.1 µM (rat); Β-1 adrenergic receptor: Ki= 13 µM (rat); Adrenergic receptor β ADRB1 & ADRB3: Ki= 13 µM (human)
pK Values :
pKa: 8.86
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DO7525000
PubChem CID :
5284443
Merck Index :
14: 7286
MDL Number :
MFCD00012605
EC Number :
200-517-3
Beilstein Registry :
4158948
SMILES :
Cl.CNC[[email protected]](O)C1=CC(O)=CC=C1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 163ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Puhl Puhl, SL. et al. (PubMed 26406609) reported that A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to (R)-(-)-Phenylephrine-induced 1-adrenergic stimulation in vivo. -SCBT Publication Review
Date published: 2015-01-06
  • y_2020, m_7, d_12, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203677, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 12ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.