(R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonist that promotes hypertrophic growth in the ventricular myocytes, and activates several MAPK signaling pathways. (R)-(-)-Phenylephrine hydrochloride is an activator of α1A-AR, α1D-AR and α1B-AR.
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Soluble in water (100 mM), DMSO (100 mM), alcohol, methanol, and ethanol (41 mg/ml at 25° C).
Store at room temperature
143-145° C (lit.)
341.1° C at 760 mmHg (Predicted)
n20D 1.57 (Predicted)
α20/D -43.9°, c = 2 in water; α20/D -51.5°, c = 2 in ethanol; α20/D -45.5°±1.5°, c = 1 in water
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PuhlPuhl, SL. et al. (PubMed 26406609) reported that A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to (R)-(-)-Phenylephrine-induced 1-adrenergic stimulation in vivo. -SCBT Publication Review
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