EOMES Inhibitors
EOMES inhibitors refer to a class of chemical compounds designed to target and modulate the activity of the EOMES (Eomesodermin) protein. Eomesodermin is a transcription factor that plays a crucial role in cellular development and differentiation, particularly in the regulation of embryonic stem cells and the formation of various tissues during embryogenesis. The inhibitors belonging to this chemical class are meticulously engineered to interfere with the normal functioning of EOMES, thereby offering researchers a valuable tool to investigate the intricate molecular pathways associated with cellular differentiation and developmental processes.
EOMES inhibitors are characterized by their ability to bind selectively to the EOMES protein, disrupting its normal interaction with DNA and other cellular components. This interference can lead to a cascade of downstream effects, influencing the expression of genes involved in cellular fate determination and differentiation. The development and study of EOMES inhibitors have expanded our understanding of the regulatory networks governing embryonic development and cellular differentiation, shedding light on fundamental biological processes. Researchers use these inhibitors in laboratory settings to manipulate cellular responses and explore the molecular mechanisms underlying developmental pathways. As a result, EOMES inhibitors serve as valuable molecular probes, contributing to the advancement of basic scientific knowledge in the fields of cell biology and developmental biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A can inhibit calcineurin, thus preventing the activation of NFAT, a transcription factor that works cooperatively with EOMES in T cell differentiation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Sirolimus binds to FKBP12 and inhibits mTOR, a kinase involved in T cell activation and proliferation, processes where EOMES is also implicated. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BET bromodomain proteins, which can regulate gene expression and indirectly affect EOMES's role in gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can cause demethylation of gene promoters, possibly affecting the expression of genes regulated by EOMES. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor which can alter chromatin structure, potentially influencing EOMES-mediated gene transcription. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, affecting AKT signaling, which may intersect with pathways involving EOMES during T cell development. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 selectively inhibits the TGF-β type I receptor ALK5, which can modulate SMAD signaling pathways involving EOMES. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $306.00 | 1 | |
This is an inhibitor of IKK, affecting NF-κB signaling, which may influence the immune response in which EOMES plays a role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which may alter AP-1 activity and thus impact the transcriptional regulation involving EOMES. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor, which can affect protein degradation pathways and may influence the stability of proteins that interact with EOMES. | ||||||