EOMES Antibody (1A8): sc-293481

EOMES Antibody (1A8) is a mouse monoclonal IgG2a kappa light chain antibody that detects EOMES protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-EOMES antibody (1A8) is available as the non-conjugated format. EOMES, or eomesodermin homolog, is a crucial transcription factor consisting of 686 amino acids in humans, sharing homology with the mouse Eomes protein and characterized by a single T-box DNA binding domain. EOMES plays a vital role in the regulation of developmental processes, particularly in the developing brain, where EOMES is localized to the nucleus. EOMES is essential for neuronal migration and division, contributing significantly to trophoblast development and the process of gastrulation. Proper functioning of EOMES is critical, as silencing EOMES can lead to severe developmental issues, including microcephaly disorders, which are marked by reduced head circumference and brain malformations. Understanding EOMES in these processes highlights EOMES importance in both normal development and potential implications of EOMES dysregulation in various neurological conditions.

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EOMES Antibody (1A8) References:

1. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain.  |  Kimura, N., et al. 1999. Brain Res Dev Brain Res. 115: 183-93. PMID: 10407135
2. Eomesodermin is required for mouse trophoblast development and mesoderm formation.  |  Russ, AP., et al. 2000. Nature. 404: 95-9. PMID: 10716450
3. Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1.  |  Ueno, M., et al. 2000. Gene. 254: 29-35. PMID: 10974533
4. Control of effector CD8+ T cell function by the transcription factor Eomesodermin.  |  Pearce, EL., et al. 2003. Science. 302: 1041-3. PMID: 14605368
5. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.  |  Intlekofer, AM., et al. 2005. Nat Immunol. 6: 1236-44. PMID: 16273099
6. Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis.  |  Baala, L., et al. 2007. Nat Genet. 39: 454-6. PMID: 17353897
7. Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression.  |  Bonnal, RJP., et al. 2021. Nat Immunol. 22: 735-745. PMID: 34017124
8. Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes.  |  Lin, YH., et al. 2023. Immunity. 56: 207-223.e8. PMID: 36580919
9. Eomesodermin-expressing type 1 regulatory (EOMES+ Tr1)-like T cells: Basic biology and role in immune-mediated diseases.  |  Geginat, J., et al. 2023. Eur J Immunol. 53: e2149775. PMID: 36653901
10. Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation.  |  Joulia, E., et al. 2024. J Exp Med. 221: PMID: 38189779
11. Eomes expression identifies the early bone marrow precursor to classical NK cells.  |  Liang, Z., et al. 2024. Nat Immunol. 25: 1172-1182. PMID: 38871999
12. Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19.  |  Yi, CH., et al. 1999. Genomics. 55: 10-20. PMID: 9888994

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EOMES Antibody (1A8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-EOMES Antibody (1A8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EOMES Antibody (1A8) Specifications

Alternate Product Name: EOMES

Product Clone Name: 1A8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 461-569

Epitope Target: EOMES

Epitope Species: human

Product Reactivity/Detection: EOMES

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for EOMES Antibody (1A8): N/A