EG384813 Inhibitors
Adam34l, a member of the disintegrin and metallopeptidase domain (ADAM) family, is predicted to play a vital role in male gonad development, with activity localized to the external side of the plasma membrane and sperm head plasma membrane. The involvement of Adam34l in extracellular processes suggests potential roles in cellular adhesion, migration, or extracellular matrix remodeling, contributing to the intricate processes associated with male gonad development and sperm function.
The inhibition of Adam34l can be achieved through targeting its metallopeptidase activity, particularly that of matrix metalloproteinases (MMPs), known to play a role in extracellular matrix remodeling. Direct inhibitors like Batimastat, SB-3CT, and Marimastat specifically target MMPs, potentially disrupting the dynamic extracellular matrix interactions crucial for male gonad development and sperm functionality. Tissue Inhibitors of Metalloproteinases (TIMPs) act indirectly by regulating MMP activity, providing an endogenous control mechanism. Additionally, compounds like GW4064 and Cilengitide influence downstream pathways associated with male gonad development, impacting Adam34l indirectly. In summary, the inhibition of Adam34l involves targeting its metallopeptidase activity, particularly through the modulation of MMPs and downstream pathways associated with male gonad development. The identified inhibitors offer a comprehensive approach to explore the intricate roles of Adam34l in cellular processes, shedding light on its involvement in male reproductive biology and providing a foundation for further experimental investigations.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $175.00 $370.00 | 24 | |
Matrix metalloproteinase (MMP) inhibitor. Batimastat directly inhibits Adam34l by targeting MMPs, which are involved in extracellular matrix remodeling, potentially impacting male gonad development and the activity of Adam34l at the plasma membrane. | ||||||
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $100.00 $380.00 | 15 | |
Gelatinase-specific MMP inhibitor. SB-3CT directly inhibits Adam34l by targeting gelatinases, potentially disrupting extracellular matrix remodeling and influencing the activity of Adam34l in male gonad development and plasma membrane interactions. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $165.00 $214.00 $396.00 $617.00 $4804.00 | 19 | |
Broad-spectrum MMP inhibitor. Marimastat directly inhibits Adam34l by targeting various MMPs, potentially impacting extracellular matrix dynamics and the function of Adam34l in male gonad development and at the plasma membrane. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $75.00 $265.00 | 55 | |
Broad-spectrum MMP inhibitor. GM6001 directly inhibits Adam34l by targeting multiple MMPs, potentially influencing extracellular matrix remodeling and the role of Adam34l in male gonad development and plasma membrane interactions. | ||||||
GW 4064 | 278779-30-9 | sc-218577 | 5 mg | $93.00 | 13 | |
FXR (Farnesoid X Receptor) agonist. GW4064 indirectly inhibits Adam34l by activating FXR, potentially modulating downstream pathways associated with male gonad development and the activity of Adam34l at the plasma membrane. | ||||||
PD166793 | 199850-67-4 | sc-202709 | 5 mg | $147.00 | 6 | |
Broad-spectrum MMP inhibitor. PD166793 directly inhibits Adam34l by targeting MMPs, potentially disrupting extracellular matrix dynamics and influencing the function of Adam34l in male gonad development and at the plasma membrane. | ||||||
MMP Inhibitor V | 223472-31-9 | sc-203139 | 2 mg | $216.00 | 2 | |
MMP Inhibitor V directly inhibits Adam34l by targeting MMP-9, potentially impacting extracellular matrix remodeling and the role of Adam34l in male gonad development and plasma membrane interactions. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $45.00 $94.00 | ||
Metalloproteinase inhibitor. Penicillamine directly inhibits Adam34l by chelating metal ions, potentially disrupting metalloproteinase activity associated with male gonad development and the function of Adam34l at the plasma membrane. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Integrin inhibitor. Cilengitide indirectly inhibits Adam34l by targeting integrins, potentially modulating cell adhesion and migration associated with male gonad development and the activity of Adam34l at the plasma membrane. | ||||||
NSC 405020 | 7497-07-6 | sc-477738 | 10 mg | $105.00 | ||
Selective MMP-9 inhibitor. NSC 405020 directly inhibits Adam34l by targeting MMP-9, potentially influencing extracellular matrix dynamics and the function of Adam34l in male gonad development and at the plasma membrane. | ||||||