Molecular structure of GW 4064, CAS Number: 278779-30-9
GW 4064 (CAS 278779-30-9)
See product citations (13)
Alternate Names:
3-(2,6-Dichlorophenyl)-4-(3′-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole
Application:
GW 4064 is a novel nonsteroidal FXR nuclear receptor activator
CAS Number:
278779-30-9
Purity:
≥98%
Molecular Weight:
542.84
Molecular Formula:
C28H22Cl3NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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GW 4064 is a selective, non-steroidal FXR (farnesoid X receptor) agonist (EC50 = 15 nM). GW 4064 displays no activity at other nuclear receptors at concentrations up to 1 μM. GW 4064 upregulates adipokine expression in preadipocytes and HepG2 cells. It can also reduce induction of proinflammatory cytokines by LPS in vitro.
GW 4064 (CAS 278779-30-9) References
- Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. | Akwabi-Ameyaw, A., et al. 2008. Bioorg Med Chem Lett. 18: 4339-43. PMID: 18621523
- FXR agonist activity of conformationally constrained analogs of GW 4064. | Akwabi-Ameyaw, A., et al. 2009. Bioorg Med Chem Lett. 19: 4733-9. PMID: 19586769
- Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors. | Singh, N., et al. 2014. Mol Endocrinol. 28: 659-73. PMID: 24597548
- GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells. | Xin, XM., et al. 2014. World J Gastroenterol. 20: 15727-35. PMID: 25400456
- GW4064 attenuates lipopolysaccharide‑induced hepatic inflammation and apoptosis through inhibition of the Toll‑like receptor 4‑mediated p38 mitogen‑activated protein kinase signaling pathway in mice. | Liu, HM., et al. 2018. Int J Mol Med. 41: 1455-1462. PMID: 29328388
- Farnesoid X Receptor Agonist GW4064 Inhibits Aromatase and ERβ Expression in Human Endometriotic Stromal Cells. | Wu, PL., et al. 2019. Reprod Sci. 26: 1111-1120. PMID: 30428773
- Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway. | Yu, JH., et al. 2019. Int J Oncol. 54: 879-892. PMID: 30747230
- FXR agonist GW4064 improves liver and intestinal pathology and alters bile acid metabolism in rats undergoing small intestinal resection. | Cao, Y., et al. 2019. Am J Physiol Gastrointest Liver Physiol. 317: G108-G115. PMID: 30920307
- Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity. | Xiong, H., et al. 2022. Hepatology. 76: 387-403. PMID: 34870866
- Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1. | Rizzolo, D., et al. 2021. Acta Pharm Sin B. 11: 3847-3856. PMID: 35024311
- Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes. | Kim, DH., et al. 2022. Redox Biol. 54: 102382. PMID: 35767918
- GW4064 Alters Gut Microbiota Composition and Counteracts Autism-Associated Behaviors in BTBR T+tf/J Mice. | Liu, J., et al. 2022. Front Cell Infect Microbiol. 12: 911259. PMID: 35811667
- Effect of FXR agonist GW4064 in the treatment of hilar cholangiocarcinoma in rats. | Wang, JP., et al. 2022. Sci Rep. 12: 18873. PMID: 36344586
Inhibitor of:
Ces1a, CYP7B1, EG384813, FXR, FXRβ, HNF-3α, HTPAP, Lamin B2, OSTβ, PDC-E2, TGR5, and Zfp13.Activator of:
14-3-3 ζ, Abcg3, ABCG5, cathepsin M, Daf2, EG623898, FXR, GPNMB, Mdr-3, NTCP, OSTα, SHP, and USP9X.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 4064, 5 mg | sc-218577 | 5 mg | $93.00 |