Molecular structure of MMP Inhibitor V, CAS Number: 223472-31-9
MMP Inhibitor V (CAS 223472-31-9)
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Alternate Names:
ONO 4817; (2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide
Application:
MMP Inhibitor V is a broad-spectrum inhibitor of MMPs
CAS Number:
223472-31-9
Purity:
≥98%
Molecular Weight:
416.47
Molecular Formula:
C22H28N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MMP Inhibitor V is a compound used extensively in biochemical research to study the regulation and activity of matrix metalloproteinases (MMPs), which are a group of enzymes involved in the degradation of the extracellular matrix. By inhibiting MMPs, MMP Inhibitor V allows researchers to probe the specific contributions of these enzymes to various physiological and pathological events. It is also used in assays to characterize the selectivity and potency of MMP actions, thereby helping to delineate their roles in matrix biology. In addition to its utility in basic research, MMP Inhibitor V aids in the exploration of the molecular mechanisms underlying the invasion and metastasis of cancer cells, which are often associated with aberrant MMP activity.
MMP Inhibitor V (CAS 223472-31-9) References
- ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. | Yamada, A., et al. 2000. Inflamm Res. 49: 144-6. PMID: 10858013
- Suppression of the development of experimentally induced uterine adenomyosis by a novel matrix metalloproteinase inhibitor, ONO-4817, in mice. | Mori, T., et al. 2001. Exp Biol Med (Maywood). 226: 429-33. PMID: 11393170
- Organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines. | Shiraga, M., et al. 2002. Cancer Res. 62: 5967-73. PMID: 12384564
- ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase. | Ito, N., et al. 2004. Biochem Biophys Res Commun. 314: 1008-13. PMID: 14751233
- A matrix metalloproteinase inhibitor, ONO-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. | Okamoto, Y., et al. 2007. Int Heart J. 48: 369-78. PMID: 17592201
- A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis. | Blackburn, JS., et al. 2009. Oncogene. 28: 4237-48. PMID: 19734937
- ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins. | Fröhlich, C., et al. 2013. Biochem J. 452: 97-109. PMID: 23458101
- Effects of combining methylprednisolone with rolipram on functional recovery in adult rats following spinal cord injury. | Yin, Y., et al. 2013. Neurochem Int. 62: 903-12. PMID: 23499793
- Expression of matrix metalloproteinase-12 in aortic dissection. | Song, Y., et al. 2013. BMC Cardiovasc Disord. 13: 34. PMID: 23642232
- Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment. | Spaeth, EL., et al. 2013. Cancer Res. 73: 5347-59. PMID: 23838935
- A substrate-optimized electrophoretic mobility shift assay for ADAM12. | Kotzsch, A., et al. 2014. Anal Biochem. 452: 34-42. PMID: 24534253
- Metalloproteinase dependent reduction of cell surface cluster determinants upon the induction of apoptosis. | Magro, A., et al. 2014. Int J Oncol. 44: 1539-50. PMID: 24626736
- Toxoplasma gondii infection shifts dendritic cells into an amoeboid rapid migration mode encompassing podosome dissolution, secretion of TIMP-1, and reduced proteolysis of extracellular matrix. | Ólafsson, EB., et al. 2018. Cell Microbiol. 20: PMID: 29119662
Inhibitor of:
ADAM7, ADAMTS-5, Angiogenesis, EG384813, MBLAC2, MCC, MMP-12, MMP-13, MMP-2, MMP-3, MMP-8, MMP-9, MT-MMP-1, neurocan, and PF4V1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP Inhibitor V, 2 mg | sc-203139 | 2 mg | $216.00 |