EG382265 Activators
Cldn34c3, identified as claudin 34C3, emerges as a pivotal player in cellular tight junction regulation, particularly within epithelial tissues. This claudin family member orchestrates the establishment and maintenance of tight junctions, integral components of intercellular adhesion and paracellular barrier function. Its predicted function centers around the modulation of cellular interactions, contributing to the integrity and selective permeability of epithelial layers. The precise orchestration of tight junctions is fundamental for cellular homeostasis, influencing critical processes such as nutrient absorption, ion transport, and the prevention of undesired paracellular leakage.
The activation of Cldn34c3 involves a sophisticated interplay of signaling pathways and cellular processes that collectively contribute to the regulation of tight junction dynamics. While not extensively elucidated, general mechanisms of activation highlight the intricate nature of Cldn34c3 control. Various biochemical and cellular pathways converge on the modulation of Cldn34c3 expression, influencing its pivotal role in tight junction assembly. These regulatory mechanisms include intracellular signaling cascades such as protein kinase A (PKA) activation through cAMP elevation, calcium-dependent pathways involving calmodulin and protein kinase C (PKC), and epigenetic modulation through histone deacetylase inhibition. Additionally, the interplay with redox-sensitive pathways, transcriptional regulation via retinoic acid-responsive elements, and the influence of vitamin derivatives contribute to the diverse repertoire of mechanisms shaping Cldn34c3 activation. Understanding the multifaceted nature of Cldn34c3 activation provides valuable insights into the intricate control of tight junctions and their physiological significance. The emerging picture suggests a finely tuned regulatory network where various cellular processes converge to modulate Cldn34c3 expression, thereby influencing the dynamics of tight junctions and contributing to the maintenance of cellular barrier function. Further exploration of these regulatory mechanisms promises to unveil additional layers of complexity in the control of Cldn34c3 and its role in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Dimethyl Sulfoxide (DMSO) acts as a cell-permeable solvent that enhances the expression of Cldn34c3. By modulating intracellular signaling cascades, particularly the PKC pathway, DMSO indirectly promotes the activation of Cldn34c3, leading to increased cellular responses related to tight junction regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, a calcium ionophore, triggers an influx of Ca2+ into cells. Elevated intracellular calcium levels stimulate calmodulin, leading to the activation of PKC. This cascade positively influences Cldn34c3 expression, promoting tight junction assembly. A23187 serves as an indirect activator through the modulation of calcium-dependent signaling pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, induces histone hyperacetylation, altering chromatin structure. This epigenetic modification positively regulates Cldn34c3 gene expression, promoting tight junction integrity. Trichostatin A acts as an indirect activator by influencing the epigenetic landscape associated with Cldn34c3 regulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, an activator of Nrf2, enhances antioxidant responses. Nrf2 activation positively influences Cldn34c3 expression by modulating redox-sensitive signaling pathways. Sulforaphane serves as an indirect activator, impacting cellular redox status and contributing to the up-regulation of Cldn34c3 involved in tight junction maintenance. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074, a Raf-1 kinase inhibitor, disrupts the Raf/MEK/ERK signaling pathway. Inhibition of this pathway indirectly up-regulates Cldn34c3 expression, as the ERK cascade negatively regulates tight junction formation. GW5074 serves as an indirect activator by modulating the Raf/MEK/ERK pathway and promoting the activation of Cldn34c3. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632, a ROCK inhibitor, disrupts actin cytoskeleton dynamics. This modulation positively impacts Cldn34c3 by preventing cytoskeletal rearrangements that negatively influence tight junction integrity. Y-27632 acts as an indirect activator, affecting cellular structures and indirectly promoting the activation of Cldn34c3 involved in tight junction regulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, disrupts TGF-β signaling. Inhibition of this pathway positively influences Cldn34c3 expression, as TGF-β negatively regulates tight junction assembly. SB431542 serves as an indirect activator by modulating the TGF-β signaling pathway and promoting the activation of Cldn34c3 involved in tight junction regulation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082, an NF-κB inhibitor, disrupts NF-κB signaling. Inhibition of this pathway positively influences Cldn34c3 expression, as NF-κB negatively regulates tight junction formation. Bay 11-7082 serves as an indirect activator by modulating the NF-κB pathway and promoting the activation of Cldn34c3 involved in tight junction regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, disrupts the PI3K/Akt signaling pathway. Inhibition of this pathway positively influences Cldn34c3 expression, as Akt negatively regulates tight junction assembly. LY294002 serves as an indirect activator by modulating the PI3K/Akt pathway and promoting the activation of Cldn34c3 involved in tight junction regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, a vitamin A derivative, acts as a transcriptional regulator. It positively modulates Cldn34c3 expression by influencing retinoic acid-responsive elements in the gene promoter. Retinoic Acid serves as an indirect activator, impacting gene transcription and promoting the activation of Cldn34c3 involved in tight junction regulation. | ||||||