EG328644 Activators
Vwa5b2, or von Willebrand factor A domain containing 5B2, plays a crucial role in various tissues, including the nervous system, pancreas trunk epithelium, and sensory organs. Its orthologous counterpart in humans suggests conserved functionality. Activation of Vwa5b2 involves intricate cellular processes influenced by specific chemicals. Retinoic Acid, for instance, activates Vwa5b2 by modulating the RAR/RXR signaling pathway, leading to transcriptional regulation of the target gene. Forskolin indirectly up-regulates Vwa5b2 by activating adenylate cyclase, triggering cAMP-dependent signaling cascades. Sodium Butyrate, acting as a histone deacetylase inhibitor, promotes Vwa5b2 expression through histone acetylation in the nucleus. Lithium Chloride enhances Vwa5b2 by inhibiting GSK-3, allowing activation of the Wnt signaling pathway. Epigallocatechin Gallate (EGCG) activates Vwa5b2 indirectly by modulating the PI3K/AKT signaling pathway, influencing cell survival and gene expression. Resveratrol stimulates Vwa5b2 by activating SIRT1, regulating cellular processes involved in gene expression modulation.
Trichostatin A activates Vwa5b2 by inhibiting histone deacetylases, leading to enhanced gene expression through chromatin remodeling. Curcumin promotes Vwa5b2 expression by modulating NF-κB signaling, influencing transcriptional regulation. 5-Aza-2'-deoxycytidine activates Vwa5b2 by inhibiting DNA methylation, altering chromatin structure, and increasing gene expression. SB-431542 indirectly up-regulates Vwa5b2 by inhibiting TGF-β signaling, preventing its inhibitory effects. Wortmannin stimulates Vwa5b2 by inhibiting PI3K, disrupting the PI3K/AKT/mTOR pathway. PMA activates Vwa5b2 by modulating PKC signaling, influencing downstream pathways in the up-regulation of the target gene. In summary, Vwa5b2, with its diverse tissue expression, undergoes activation influenced by various chemicals targeting specific signaling pathways. Understanding these activation mechanisms contributes to unraveling the intricacies of Vwa5b2's functional role in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates Vwa5b2 by modulating the RAR/RXR signaling pathway, influencing transcriptional regulation of the target gene. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate promotes Vwa5b2 expression through histone acetylation, acting as a histone deacetylase inhibitor in the nucleus. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride enhances Vwa5b2 by inhibiting GSK-3, preventing its negative regulation and allowing activation of the Wnt signaling pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates Vwa5b2 indirectly by modulating the PI3K/AKT signaling pathway, influencing cell survival and gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol stimulates Vwa5b2 by activating SIRT1, which regulates cellular processes involved in the modulation of gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A activates Vwa5b2 by inhibiting histone deacetylases, leading to enhanced gene expression through chromatin remodeling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin promotes Vwa5b2 expression by modulating NF-κB signaling, influencing the transcriptional regulation of the target gene. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine activates Vwa5b2 by inhibiting DNA methylation, leading to altered chromatin structure and increased gene expression. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 indirectly up-regulates Vwa5b2 by inhibiting TGF-β signaling, preventing its inhibitory effects on the target gene. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin stimulates Vwa5b2 by inhibiting PI3K, disrupting the PI3K/AKT/mTOR pathway and enhancing the activation of the target gene. | ||||||