E130012A19Rik Inhibitors
EPOP, or elongin BC and polycomb repressive complex 2 associated protein, plays a critical role in various cellular processes. It is involved in chromatin binding, histone H2B conserved C-terminal lysine deubiquitination, regulation of transcription by RNA polymerase II, and stem cell differentiation. EPOP is part of the ESC/E(Z) complex and the elongin complex, highlighting its multifaceted functions within these molecular assemblies.
The inhibition of EPOP involves targeting its specific functions and associated pathways. The chemicals listed above act as direct or indirect inhibitors by modulating key cellular processes. For instance, Trichostatin A and SAHA, as HDAC inhibitors, impact chromatin structure and may disrupt EPOP's chromatin binding activity, affecting its role in histone H2B deubiquitination. (+/-)-JQ1, a BET bromodomain inhibitor, indirectly influences EPOP by altering the dynamics of the ESC/E(Z) complex, impacting its role in transcriptional regulation. MLN4924, an NEDD8-activating enzyme inhibitor, may disrupt EPOP's involvement in the elongin complex, influencing its role in transcription by RNA polymerase II. In summary, the diverse inhibitors identified provide insights into potential strategies for modulating EPOP function. Understanding the specific pathways and cellular processes associated with EPOP is crucial for developing targeted approaches to inhibit its activity, shedding light on its intricate role in chromatin dynamics, transcriptional regulation, and stem cell differentiation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor disrupting chromatin remodeling, potentially impacting EPOP's chromatin binding activity and leading to inhibition of its role in histone H2B conserved C-terminal lysine deubiquitination. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor modulating transcriptional regulation, indirectly influencing EPOP by altering the dynamics of the ESC/E(Z) complex in which EPOP is involved. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
NEDD8-activating enzyme inhibitor disrupting protein neddylation, potentially affecting EPOP's involvement in the elongin complex and leading to inhibition of its function in regulating transcription by RNA polymerase II. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EZH2 inhibitor disrupting the activity of the polycomb repressive complex 2, indirectly impacting EPOP as part of the ESC/E(Z) complex and potentially inhibiting its role in stem cell differentiation. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
CDK inhibitor affecting cell cycle progression, potentially influencing EPOP's role in stem cell differentiation by modulating cell cycle dynamics upstream of neuron fate commitment. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor altering chromatin structure, potentially impacting EPOP's chromatin binding activity and leading to inhibition of its role in histone H2B conserved C-terminal lysine deubiquitination. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $122.00 $219.00 | 2 | |
MDM2 inhibitor disrupting the p53 pathway, indirectly influencing EPOP by modulating the transcriptional regulatory network and potentially impacting its role in stem cell differentiation. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
JMJD3 inhibitor affecting histone demethylation, potentially influencing EPOP's involvement in the polycomb repressive complex 2 and leading to inhibition of its role in regulating transcription by RNA polymerase II. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
p300/CBP inhibitor impacting histone acetylation, potentially affecting EPOP's chromatin binding activity and leading to inhibition of its role in histone H2B conserved C-terminal lysine deubiquitination. | ||||||
BAY 61-3606 | sc-507485 | 2 mg | $345.00 | 1 | ||
Syk kinase inhibitor modulating signaling pathways, potentially influencing EPOP indirectly by altering downstream cascades and impacting its role in histone H2B conserved C-terminal lysine deubiquitination. | ||||||