DHDDS Activators
DHDDS plays a pivotal role in the biosynthesis of dolichol, a compound intricately woven into the fabric of the N-glycosylation pathway in cellular systems. Dolichol synthesis and its subsequent involvement in protein glycosylation can be influenced by various signaling mechanisms. Chemicals like Forskolin and Phorbol 12-myristate 13-acetate, which elevate cAMP levels and activate protein kinase C respectively, illuminate the influence of cyclic nucleotides and kinases on DHDDS activity. On another spectrum, LY294002 and U0126 offer insight into the broader cellular signaling pathways of PI3K and MAPK, delineating their sway over lipid metabolic enzymes like DHDDS.
Chemicals associated with lipid metabolism pathways, including Mevalonate, Retinoic acid, and Cerulenin, emphasize DHDDS's integration within a dense web of metabolic cascades. The role of Simvastatin in cholesterol synthesis underscores the intricate link between cholesterol and dolichol pathways, suggesting a modulatory effect on DHDDS. Moreover, agents like Manumycin A and Rapamycin hint at the expansive horizon of lipid signaling and its intersections with enzymes pivotal for glycosylation. Chemicals like W-7 hydrochloride and GW4869 further refine our understanding, anchoring DHDDS within the broader spectrum of calcium-sensitive processes and sphingolipid metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, which can regulate various proteins and potentially enhance DHDDS function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which might modulate enzymatic functions, including DHDDS. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor which can influence lipid metabolism and related enzymes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Affects lipid metabolism and might regulate DHDDS indirectly. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Fatty acid synthase inhibitor which can impact lipid metabolism. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
HMG-CoA reductase inhibitor affecting cholesterol synthesis, which is related to dolichol synthesis. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Farnesyltransferase inhibitor, can impact lipid signaling and related enzymes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor which can indirectly influence lipid metabolism and related enzymatic processes. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Calcium/calmodulin antagonist potentially influencing calcium-sensitive metabolic processes. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
Neutral sphingomyelinase inhibitor, influencing sphingolipid metabolism and related pathways. | ||||||