DDX47 Inhibitors
DDX47 inhibitors belong to a distinctive chemical class that targets a specific RNA helicase enzyme known as DDX47, a member of the DEAD-box family of RNA helicases. DEAD-box helicases are pivotal in RNA metabolism, playing critical roles in unwinding RNA duplexes and facilitating various aspects of RNA processing and translation. DDX47, in particular, is recognized for its involvement in ribosome biogenesis and pre-mRNA splicing, contributing to the dynamic and intricate cellular processes essential for proper gene expression. The development of inhibitors specifically designed for DDX47 marks a significant stride in the realm of molecular biology and cellular regulation.
DDX47 inhibitors typically encompasses elements tailored to interact with the catalytic core of the DDX47 enzyme, disrupting its helicase activity. These small molecules are designed to bind selectively to the ATP-binding site of DDX47, inhibiting its ATPase and helicase functions. By impeding the normal functioning of DDX47, these inhibitors exert a modulatory effect on RNA processing and related cellular activities. Understanding the structural features and mechanisms of action of DDX47 inhibitors provides valuable insights for researchers aiming to unravel the intricate web of cellular processes governed by RNA helicases, thereby contributing to the broader understanding of molecular biology and potential applications in the modulation of gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Interferes with ATP binding sites on proteins, which can disrupt the ATPase activity of DDX47. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Interacts with nucleic acids, potentially hindering DDX47's ability to bind and remodel RNA. | ||||||
Pifithrin-μ | 64984-31-2 | sc-203195 sc-203195A | 10 mg 50 mg | $130.00 $379.00 | 4 | |
Alters protein-protein interactions, which can affect DDX47's function in the RNA processing complexes. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Binds to and inhibits several kinases, which may indirectly affect the phosphorylation state and activity of DDX47. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Forms DNA adducts, potentially affecting DDX47's substrate availability or interaction with RNA. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Known to modulate protein activity, could affect DDX47 indirectly by altering signaling pathways. | ||||||
Silvestrol | 697235-38-4 | sc-507504 | 1 mg | $920.00 | ||
Target eukaryotic translation initiation, which may indirectly affect DDX47's role in RNA processing. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Inhibits translation initiation and could indirectly influence DDX47 function by modulating RNA turnover. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Mimics aminoacyl-tRNAs, potentially disrupting processes DDX47 is involved in by prematurely terminating protein synthesis. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Binds to Hsp90, potentially disrupting its chaperone function which can affect the stability and function of client proteins like DDX47. | ||||||