DDX47 Activators
DDX47 is a member of the DEAD-box protein family, characterized by the conserved amino acid sequence Asp-Glu-Ala-Asp (DEAD). These proteins function as RNA helicases, playing pivotal roles in various aspects of RNA metabolism, including splicing, transport, degradation, and ribosome biogenesis. Specifically, DDX47 is integral to the processing of ribosomal RNA (rRNA) and the assembly of ribosomal subunits, which are essential for protein synthesis within the cell. It operates by unwinding complex RNA secondary structures using energy derived from ATP hydrolysis. This unwinding is crucial for the proper folding and maturation of rRNA, ensuring the fidelity and efficiency of ribosome assembly. Activation of DDX47 enhances its helicase activity, leading to improved efficiency in these critical cellular processes.
DDX47 activators are a class of chemical compounds or molecules designed to enhance the enzymatic activity of the DDX47 protein. By binding to DDX47, these activators can induce conformational changes that increase its ATPase and helicase activities. This augmentation can result in more efficient unwinding of RNA structures, promoting accurate rRNA processing and ribosome biogenesis. Studying DDX47 activators is significant for understanding the regulation of protein synthesis at the molecular level. They serve as valuable tools in biochemical and molecular biology research, helping to elucidate the detailed mechanisms by which RNA helicases function and influence cellular processes such as gene expression, cell growth, and proliferation. Additionally, investigating these activators contributes to the broader knowledge of RNA metabolism and its impact on cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP serves as the primary energy currency of the cell and is required for the helicase activity of DDX47. Binding to ATP, DDX47 undergoes a conformational change that enhances its RNA helicase activity, facilitating the unwinding of RNA structures during processes such as ribosome biogenesis and splicing. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
MgCl2 is a cofactor that is necessary for the ATPase activity of DDX47. The presence of magnesium ions stabilizes the binding of ATP to DDX47, which is crucial for its catalytic activity and, by extension, its role in RNA metabolism. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a structural cofactor for many RNA-binding proteins and is presumed to stabilize the structure of DDX47, which may enhance its RNA helicase activity by ensuring proper folding and function. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine has been shown to facilitate RNA folding and stabilize RNA-protein interactions. By stabilizing the structure of RNA, spermidine can enhance the helicase activity of DDX47 by making substrates more accessible. | ||||||
Sodium molybdate dihydrate | 10102-40-6 | sc-203391 sc-203391A sc-203391B | 5 g 100 g 500 g | $36.00 $66.00 $301.00 | ||
Sodium molybdate is a source of molybdenum ions, which can act as cofactors for certain enzymes. While not directly linked to DDX47, molybdenum cofactors can influence RNA processing enzymes that may work in concert with DDX47, potentially enhancing its functional role. | ||||||
Guanosine-5′-monophosphate | 85-32-5 | sc-295032 sc-295032A sc-295032B | 1 g 2.5 g 5 g | $322.00 $622.00 $1051.00 | 5 | |
5'-GMP can bind to RNA, affecting its structure and potentially making it a more suitable substrate for the RNA helicase activity of DDX47, thereby enhancing its function. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine contributes to nitric oxide (NO) synthesis, which can modulate various signaling pathways, including those involving RNA metabolism. NO may influence the cellular location and function of RNA helicases like DDX47 indirectly. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $55.00 $155.00 $285.00 $455.00 | 5 | |
Potassium chloride is essential for maintaining the ionic strength and osmolarity of the cellular environment, which can influence the activity of RNA helicases. Proper ionic conditions are needed for the optimal activity of DDX47. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is known to affect multiple signal transduction pathways, including those involving cAMP/PKA. Although not directly linked to DDX47, caffeine can create a cellular environment that indirectly enhances RNA processing and helicase activities. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a crucial coenzyme in redox reactions but also serves as a substrate for ADP-ribosylation, which can modify protein function. Such modifications may indirectly affect the activity of RNA helicases like DDX47 in the context of RNA metabolism. | ||||||