DCAF17 Activators
DCAF17, also known as DDB1 and CUL4 associated factor 17, is a human protein encoded by the DCAF17 gene. It is implicated in a range of cellular processes due to its role as a substrate receptor for CUL4-DDB1 ubiquitin ligase complex. The ubiquitin-proteasome system, where DCAF17 plays a part, is crucial for protein degradation and turnover, which is essential for maintaining cellular homeostasis.Mutations in the DCAF17 gene are associated with Woodhouse-Sakati syndrome, a rare autosomal recessive disorder. This syndrome is characterized by a spectrum of features including hypogonadism, diabetes mellitus, alopecia, intellectual disability, and deafness. The protein's malfunction due to genetic alterations can lead to this wide array of systemic dysfunctions, highlighting its significance in human biology.
DCAF17's exact molecular function is not fully elucidated, but it is known to interact with multiple proteins and has been linked to the regulation of transcription and DNA repair. It is a part of the complex network of protein interactions that govern cell cycle progression, DNA damage responses, and perhaps even the epigenetic regulation of gene expression. Ongoing research aims to unravel the complete range of DCAF17's biological activities and its as a target for intervention in the disorders associated with its dysfunction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate gene expression through retinoic acid receptors, which can affect a variety of genes including those involved in cell differentiation and proliferation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methylation inhibitor, 5-azacytidine can lead to the demethylation of gene promoters, potentially increasing the transcription of certain genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor can cause chromatin to become more open, facilitating access of transcription machinery to gene promoters. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing levels of cAMP, which can lead to the activation of protein kinase A and modulation of transcription factor activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is another histone deacetylase inhibitor which can lead to changes in chromatin structure and gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
As a polyphenol, resveratrol influences various signaling pathways and may affect gene expression through its action on sirtuins and other factors. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, is known to affect gene expression through the Nrf2 pathway, which regulates the expression of various genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate the activity of various transcription factors, potentially altering gene expression profiles. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, dexamethasone can regulate gene expression by activating the glucocorticoid receptor. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences multiple signaling pathways including the Wnt signaling pathway, which can affect gene expression. | ||||||