Dab2 Activators
Dab2 activators comprise a collection of chemical agents that either directly or indirectly influence Disabled-2 (Dab2), a multifunctional adaptor protein involved in cellular processes such as endocytosis, signal transduction, and cell differentiation. While the identification of direct activators may be limited, a comprehensive understanding of Dab2-related signaling pathways allows for the exploration of chemicals that can modulate its activity. Among the compounds listed, several inhibitors, such as SB202190, LY294002, and Wortmannin, target key signaling pathways associated with Dab2, including p38 MAPK and PI3K. These inhibitors indirectly impact Dab2 activity by disrupting shared downstream effectors, potentially modulating cellular processes regulated by Dab2. Additionally, MK-2206 and U0126 target specific components of the PI3K/Akt and MAPK/ERK pathways, respectively, which intersect with Dab2 signaling. By blocking Akt and MEK, these chemicals may indirectly influence Dab2 activity and, consequently, cellular processes associated with Dab2 function.
Inhibitors like SU5402 and PD98059 disrupt FGFR and MEK pathways, respectively, both of which are interconnected with Dab2 signaling. These compounds may indirectly affect Dab2 activity through shared downstream effectors, potentially modulating cellular processes regulated by Dab2. Furthermore, chemicals like PP2, GSK-3 Inhibitor IX, NSC 87877, and 17-AAG target Src family kinases, GSK-3, Grb2, and Hsp90, respectively, all of which play roles in Dab2-related cellular processes. These activators may indirectly influence Dab2 activity through their impact on shared downstream effectors, offering potential modulation of cellular processes regulated by Dab2. In conclusion, the diverse class of Dab2 activators provides valuable tools for investigating and understanding the intricate regulatory networks involving Dab2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB202190 inhibits p38 mitogen-activated protein kinase (MAPK), which is involved in cellular processes related to Dab2 function. By blocking p38 MAPK, SB202190 may indirectly influence Dab2 activity through shared downstream effectors, potentially modulating cellular processes regulated by Dab2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits phosphoinositide 3-kinase (PI3K), a pathway associated with Dab2 signaling. By disrupting PI3K, LY294002 may indirectly affect Dab2 activity through shared downstream effectors, potentially influencing cellular processes regulated by Dab2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3K inhibitor, disrupts the PI3K pathway, which is implicated in cellular processes regulated by Dab2. By inhibiting PI3K, Wortmannin may indirectly affect Dab2 activity through shared downstream effectors, potentially modulating cellular processes influenced by Dab2. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206 inhibits Akt, a downstream effector of PI3K in the Dab2 pathway. By blocking Akt, MK-2206 may indirectly impact Dab2 activity, potentially influencing cellular processes regulated by Dab2. | ||||||
Doramapimod | 285983-48-4 | sc-300502 sc-300502A sc-300502B | 25 mg 50 mg 100 mg | $149.00 $281.00 $459.00 | 2 | |
BIRB 796 inhibits p38 MAPK, a kinase implicated in cellular processes related to Dab2 function. By blocking p38 MAPK, BIRB 796 may indirectly affect Dab2 activity through shared downstream effectors, potentially modulating cellular processes regulated by Dab2. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
SU5402 inhibits fibroblast growth factor receptor (FGFR) signaling, a pathway interconnected with Dab2 signaling. The inhibition of FGFR by SU5402 may indirectly influence Dab2 activity through shared downstream effectors, potentially modulating cellular processes regulated by Dab2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits MEK, a kinase in the MAPK/ERK pathway associated with Dab2 signaling. By blocking MEK, PD98059 may indirectly influence Dab2 activity through shared downstream effectors, potentially modulating cellular processes regulated by Dab2. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 inhibits Src family kinases, which are involved in cellular processes related to Dab2 function. By blocking Src family kinases, PP2 may indirectly affect Dab2 activity through shared downstream effectors, potentially modulating cellular processes regulated by Dab2. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 Inhibitor IX inhibits glycogen synthase kinase-3 (GSK-3), a kinase implicated in Dab2-related cellular processes. By blocking GSK-3, this inhibitor may indirectly influence Dab2 activity through shared downstream effectors, potentially modulating cellular processes regulated by Dab2. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $137.00 | 12 | |
NSC 87877 inhibits Grb2, an adaptor protein involved in cellular processes related to Dab2 function. By blocking Grb2, NSC 87877 may indirectly affect Dab2 activity through shared downstream effectors, potentially modulating cellular processes regulated by Dab2. | ||||||