Dab2 Inhibitors
Dab2 inhibitors constitute a diverse group of chemicals designed to modulate the function of Disabled-2 (Dab2), a key player in cellular processes such as clathrin-mediated endocytosis and cytoskeletal dynamics. While the number of direct inhibitors targeting Dab2 is limited, a range of compounds exerts their effects by influencing the broader cellular mechanisms associated with Dab2. Among the indirect inhibitors, Y-27632 and Dynasore play pivotal roles in impacting Dab2-mediated endocytosis. Y-27632 achieves this by regulating Rho-associated protein kinase (ROCK), a key player in the actin cytoskeleton dynamics that influence endocytosis processes. Dynasore, on the other hand, interferes with dynamin, a GTPase involved in the scission of clathrin-coated vesicles during endocytosis. These compounds provide researchers with effective tools to dissect and manipulate the intricate processes associated with Dab2-mediated endocytosis.
Chlorpromazine and Pitstop represent another category of inhibitors that disrupt clathrin-mediated endocytosis, impacting Dab2-dependent internalization processes. By targeting clathrin-coated vesicle formation, these compounds contribute to the modulation of Dab2 function within the cellular context. Additionally, Nocodazole and Jasplakinolide exert their effects by influencing microtubule and actin dynamics, respectively. These cytoskeletal elements are integral to Dab2-mediated endocytosis, making these compounds valuable in unraveling the complex interplay between Dab2 and the cytoskeleton. Dynarrestin and IPA-3 further expand the repertoire of Dab2 inhibitors by interfering with dynamin and non-receptor tyrosine kinases. Dynarrestin's influence on dynamin directly impacts endocytic processes, while IPA-3, as a non-receptor tyrosine kinase inhibitor, plays a role in regulating signaling pathways associated with Dab2. Both compounds contribute to the modulation of Dab2-associated cellular processes, offering researchers additional tools to explore the diverse regulatory mechanisms of Dab2. In summary, the class of Dab2 inhibitors presents a wide array of compounds that serve as valuable tools for investigating the intricate regulatory mechanisms of Dab2 function, particularly in the realms of endocytosis and cytoskeletal dynamics.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor that indirectly modulates Dab2. By inhibiting ROCK, Y-27632 disrupts the actin cytoskeleton dynamics, influencing Dab2-mediated endocytosis and cellular processes. This indirect modulation highlights Y-27632 as a compound capable of affecting Dab2 function through the regulation of the actin cytoskeleton. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a dynamin inhibitor that indirectly influences Dab2-mediated endocytosis. By blocking dynamin, Dynasore disrupts clathrin-mediated endocytosis, impacting Dab2-dependent internalization processes. This indirect modulation positions Dynasore as a compound capable of influencing Dab2 function through interference with the endocytic machinery. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine is a calmodulin inhibitor that indirectly modulates Dab2. By inhibiting calmodulin, Chlorpromazine disrupts clathrin-mediated endocytosis, influencing Dab2-dependent internalization processes. This indirect modulation highlights Chlorpromazine as a compound capable of affecting Dab2 function through interference with the calmodulin-dependent regulation of endocytosis. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that indirectly influences Dab2-mediated endocytosis. By disrupting microtubule dynamics, Nocodazole alters endocytic trafficking processes, impacting Dab2-dependent internalization. This indirect modulation positions Nocodazole as a compound capable of influencing Dab2 function through the regulation of microtubule-dependent endocytic processes. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is a clathrin inhibitor that indirectly modulates Dab2-mediated endocytosis. By blocking clathrin-mediated endocytosis, Pitstop 2 disrupts the internalization processes that involve Dab2. This indirect modulation highlights Pitstop 2 as a compound capable of affecting Dab2 function through interference with the clathrin-dependent regulation of endocytosis. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is an actin polymerization inhibitor that indirectly influences Dab2-mediated endocytosis. By disrupting actin dynamics, Latrunculin A interferes with Dab2-dependent endocytic processes, impacting cellular internalization. This indirect modulation positions Latrunculin A as a compound capable of affecting Dab2 function through the regulation of actin-dependent endocytosis. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an actin polymerization inhibitor that indirectly influences Dab2-mediated endocytosis. By disrupting actin dynamics, Cytochalasin D interferes with Dab2-dependent endocytic processes, impacting cellular internalization. This indirect modulation positions Cytochalasin D as a compound capable of affecting Dab2 function through the regulation of actin-dependent endocytosis. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is an actin stabilizer that indirectly influences Dab2-mediated endocytosis. By stabilizing actin filaments, Jasplakinolide modulates Dab2-dependent endocytic processes, impacting cellular internalization. This indirect modulation highlights Jasplakinolide as a compound capable of affecting Dab2 function through the regulation of actin dynamics associated with endocytosis. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK666 is an Arp2/3 complex inhibitor that indirectly modulates Dab2-mediated endocytosis. By inhibiting the Arp2/3 complex, CK666 disrupts actin nucleation and dynamics, influencing Dab2-dependent endocytic processes. This indirect modulation positions CK666 as a compound capable of affecting Dab2 function through interference with the Arp2/3 complex-mediated regulation of actin polymerization during endocytosis. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
IPA-3 is a non-receptor tyrosine kinase inhibitor that indirectly influences Dab2. By blocking non-receptor tyrosine kinases, IPA-3 disrupts the signaling pathways associated with Dab2 function, impacting cellular processes regulated by Dab2. This indirect modulation highlights IPA-3 as a compound capable of affecting Dab2 function through interference with non-receptor tyrosine kinase-mediated regulation of Dab2-associated pathways. | ||||||