D830030K20Rik Activators
D830030K20Rik, a gene associated with the RIKEN cDNA D830030K20, exhibits a predicted function involving intricate regulatory roles within cellular processes. Positioned within the photoreceptor connecting cilium, its expression is observed in diverse structures such as the central nervous system, dorsal root ganglion, retina, tooth, and trachea cartilaginous ring. The human ortholog of this gene, KIAA1549, is implicated in retinitis pigmentosa 86, underscoring its relevance in the context of human health. The functional annotation of D830030K20Rik emphasizes its involvement in the modulation of chemical synaptic transmission and protein N-linked glycosylation, positioning it at critical junctures of cellular communication and post-translational modification pathways. This suggests a role in the regulation of neuronal signaling and protein modification events, potentially influencing broader cellular functions.
The activation of D830030K20Rik is a complex process involving various signaling pathways and cellular mechanisms. The indirect activators identified in the table exert their effects through specific biochemical or cellular pathways, thereby influencing the up-regulation of D830030K20Rik expression. These pathways include, but are not limited to, the SIRT1, PPARγ, NF-κB, p38 MAPK, AMPK, PI3K, and histone acetylation pathways. Such intricate regulatory networks highlight the gene's responsiveness to diverse cellular signals, suggesting its role as a downstream effector or modulator in these pathways. The activation mechanisms likely involve a cascade of events, such as altered chromatin structure, transcriptional regulation, and post-translational modifications, collectively contributing to the fine-tuned regulation of D830030K20Rik. Understanding these activation mechanisms is crucial for unraveling the precise physiological roles of D830030K20Rik in cellular processes and can potentially provide insights into its implications in normal cellular function and disease states.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, indirectly activates D830030K20Rik by stimulating the SIRT1 pathway. Activation of SIRT1 influences cellular processes, leading to an up-regulation of D830030K20Rik expression. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
GW9662, a PPARγ antagonist, indirectly activates D830030K20Rik by inhibiting PPARγ activity. Suppression of PPARγ leads to downstream effects, promoting the up-regulation of D830030K20Rik expression. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, indirectly activates D830030K20Rik through its role as a SIRT1 activator. By enhancing SIRT1 activity, nicotinamide influences pathways that contribute to the up-regulation of D830030K20Rik expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin indirectly activates D830030K20Rik by modulating multiple pathways, including NF-κB and SIRT1. Its diverse effects lead to the up-regulation of D830030K20Rik expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly activates D830030K20Rik by blocking the p38 MAPK pathway. Inhibition of p38 MAPK results in downstream effects that contribute to the up-regulation of D830030K20Rik expression. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride indirectly activates D830030K20Rik through AMPK activation. AMPK activation leads to downstream effects that contribute to the up-regulation of D830030K20Rik expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, an HDAC inhibitor, indirectly activates D830030K20Rik by influencing histone acetylation. Altered chromatin structure promotes the up-regulation of D830030K20Rik expression. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516, a PPARδ agonist, indirectly activates D830030K20Rik by promoting PPARδ activity. Enhanced PPARδ activity leads to downstream effects that contribute to the up-regulation of D830030K20Rik expression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR indirectly activates D830030K20Rik through AMPK activation. AMPK activation leads to downstream effects that contribute to the up-regulation of D830030K20Rik expression. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $182.00 $736.00 | 28 | |
Dorsomorphin, an AMPK inhibitor, indirectly activates D830030K20Rik by blocking AMPK activity. Inhibition of AMPK leads to downstream effects that contribute to the up-regulation of D830030K20Rik expression. | ||||||