D6Wsu116e Activators
Washc2, a subunit of the WASH complex, is predicted to play a crucial role in endosome-related processes, such as protein localization to endosomes and retrograde transport from endosomes to the Golgi apparatus. To modulate Washc2 activity, we identified a set of 12 chemicals with potential direct or indirect activating effects. These chemicals target various signaling pathways and cellular processes, influencing phosphatidylinositol phosphate binding, actin cytoskeleton dynamics, and ion transport, among others. Notable activators include rapamycin, wortmannin, and bafilomycin A1, which indirectly impact Washc2 by modulating mTOR, PI3K, and V-ATPase, respectively.
Additionally, several chemicals, such as jasplakinolide and EHop-016, directly target actin dynamics and Rac1, potentially influencing Washc2 activation. These findings shed light on the intricate regulatory mechanisms of Washc2 and provide insights into its involvement in endosome-related functions. Understanding the activation of Washc2 may contribute to the broader comprehension of cellular trafficking processes and unveil avenues for diseases associated with aberrant endosomal function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, may indirectly activate Washc2. By inhibiting mTOR, rapamycin influences retrograde transport and endosome functions, potentially impacting Washc2. The inhibition of mTOR could contribute to the enhanced activation of Washc2, promoting its role in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3K inhibitor, may indirectly activate Washc2. Inhibiting PI3K affects phosphatidylinositol phosphate binding, potentially impacting Washc2. Wortmannin's modulation of PI3K signaling could contribute to the enhanced activation of Washc2, promoting its function in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1, a V-ATPase inhibitor, may indirectly activate Washc2. By inhibiting V-ATPase, bafilomycin A1 influences endosomal functions, potentially impacting Washc2. The inhibition of V-ATPase could contribute to the enhanced activation of Washc2, promoting its role in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, may indirectly activate Washc2. Inhibiting PI3K affects phosphatidylinositol phosphate binding, potentially impacting Washc2. LY294002's modulation of PI3K signaling could contribute to the enhanced activation of Washc2, promoting its function in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a MEK inhibitor, may indirectly activate Washc2. Inhibiting MEK affects the MAPK/ERK signaling pathway, potentially impacting Washc2. U0126's modulation of MAPK/ERK signaling could contribute to the enhanced activation of Washc2, promoting its role in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $240.00 | 29 | |
Latrunculin B, an actin polymerization inhibitor, may indirectly activate Washc2. By influencing actin cytoskeleton dynamics, latrunculin B could impact retrograde transport and endosome functions, potentially promoting Washc2 activation. The modulation of actin dynamics may contribute to the enhanced function of Washc2 in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2, a Src family kinase inhibitor, may indirectly activate Washc2. Inhibiting Src family kinases influences retrograde transport and endosome functions, potentially impacting Washc2. PP2's modulation of Src family kinase signaling could contribute to the enhanced activation of Washc2, promoting its role in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, may indirectly activate Washc2. Inhibiting TGF-β signaling influences retrograde transport and endosome functions, potentially impacting Washc2. SB431542's modulation of TGF-β signaling could contribute to the enhanced activation of Washc2, promoting its role in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin, a sodium ionophore, may indirectly activate Washc2. By influencing ion transport, monensin could impact retrograde transport and endosome functions, potentially promoting Washc2 activation. The modulation of ion transport may contribute to the enhanced function of Washc2 in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
EHop-016, a Rac1 inhibitor, may indirectly activate Washc2. Inhibiting Rac1 affects actin cytoskeleton dynamics, potentially impacting retrograde transport and endosome functions of Washc2. EHop-016's modulation of Rac1 signaling could contribute to the enhanced activation of Washc2, promoting its role in protein localization to endosomes and retrograde transport from endosome to Golgi. | ||||||