D6Wsu116e Inhibitors
The Washc2 protein, a critical component of the WASH complex, plays a pivotal role in cellular processes related to endosomal dynamics and retrograde transport, specifically endosome-to-Golgi transport. Washc2 is predicted to enable phosphatidylinositol phosphate and phosphatidylinositol-3,4-bisphosphate binding activities, contributing to its involvement in essential functions such as protein localization to endosomes and retromer complex binding. The intricate interplay of Washc2 in these processes underscores its significance in regulating intracellular trafficking mechanisms. Inhibition of Washc2 can be achieved through the targeted use of specific chemicals, acting as direct or indirect inhibitors. Wortmannin, for instance, disrupts the phosphoinositide signaling cascade by inhibiting phosphatidylinositol 3-kinase (PI3K), thereby impacting Washc2's predicted binding activities and functions related to retrograde transport. Similarly, LY294002, another PI3K inhibitor, influences cellular processes linked to phosphoinositide signaling, indirectly inhibiting Washc2 and affecting its role in endosome-to-Golgi retrograde transport.
In summary, the chemical class of Washc2 inhibitors encompasses compounds that target various signaling pathways and molecular components linked to phosphoinositide signaling, cytoskeletal dynamics, and retrograde transport processes. These inhibitors provide valuable tools for studying the intricate regulatory mechanisms involving Washc2, shedding light on its essential role in endosomal dynamics and protein transport. Understanding the detailed biochemical and cellular effects of Washc2 inhibitors contributes to unraveling the complexity of intracellular trafficking and holds potential implications for broader research in cell biology and related fields.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits phosphatidylinositol 3-kinase (PI3K), disrupting the PI3K/AKT pathway. Alters cellular processes related to phosphoinositide signaling, indirectly inhibiting Washc2 by influencing its predicted phosphatidylinositol phosphate and phosphatidylinositol-3,4-bisphosphate binding activities, critical for endosome-to-Golgi retrograde transport. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Blocks phosphatidylinositol 3-kinase (PI3K), disrupting the PI3K/AKT pathway. Influences cellular processes linked to phosphoinositide signaling, indirectly inhibiting Washc2 by impacting its predicted phosphatidylinositol phosphate and phosphatidylinositol-3,4-bisphosphate binding activities crucial for endosome-to-Golgi retrograde transport. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Inhibits ADP-ribosylation factor (ARF) and disrupts vesicular trafficking. By hindering protein transport, indirectly impacts Washc2 function in retromer complex binding and endosome-to-Golgi retrograde transport. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $115.00 $1056.00 | 7 | |
A dual Src/Abl kinase inhibitor, Saracatinib influences signaling pathways upstream of protein transport. Impacts Washc2 indirectly by modulating Src kinase activity, potentially altering the protein's role in retromer complex binding and endosome-to-Golgi retrograde transport. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
A Rac GTPase inhibitor, EHop-016 influences signaling pathways upstream of protein transport. Indirectly inhibits Washc2 by modulating Rac GTPase, potentially disrupting its role in endosome-to-Golgi retrograde transport and retromer complex binding. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Inhibits the Arp2/3 complex, affecting actin polymerization. By disrupting cytoskeletal dynamics, indirectly influences Washc2's involvement in protein localization to endosomes. Alters the structural framework crucial for retrograde transport processes and the function of the retromer complex. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
Inhibits PAK1, impacting cytoskeletal dynamics. Indirectly influences Washc2 by disrupting actin polymerization and protein transport. Alters the structural framework crucial for retrograde transport processes and the function of the retromer complex. | ||||||
HPI-4 | 302803-72-1 | sc-358720 sc-358720A | 5 mg 25 mg | $136.00 $541.00 | ||
Inhibits the dynein motor protein, disrupting retrograde transport along microtubules. Indirectly influences Washc2 by impacting the transport machinery. Alters endosomal processes and retromer complex binding by hindering the dynein-dependent movement crucial for endosome-to-Golgi retrograde transport. | ||||||