D10627 Activators
Zfp930, a zinc finger protein, plays a pivotal role in cellular processes through its predicted DNA-binding transcription activator activity, particularly RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding. Active in the nucleus and expressed in the metanephros and testis, Zfp930 shares orthology with human ZNF101 and ZNF699. Activation of Zfp930 involves a diverse array of chemical activators that directly or indirectly modulate its function. Direct activators include natural compounds like Curcumin, Resveratrol, and EGCG, which enhance Zfp930's DNA-binding activity and promote its involvement in transcriptional regulation.
Indirect activators encompass chemical inhibitors affecting epigenetic modifications and signaling pathways. Inhibitors like 5-Aza-2'-deoxycytidine and Trichostatin A alter DNA methylation and histone acetylation, respectively, influencing the epigenetic landscape to favor Zfp930-mediated transcriptional regulation. Additionally, signaling pathway modulators like Dexamethasone, SB431542, and Wortmannin impact glucocorticoid, TGF-β, and PI3-kinase signaling, respectively, indirectly enhancing Zfp930's engagement in RNA polymerase II-dependent transcription. In summary, the multifaceted activation of Zfp930 highlights its versatile role in gene regulation, bridging epigenetic and signaling pathways to finely tune transcriptional responses. This comprehensive understanding of Zfp930 activation mechanisms provides insights into its regulatory network and potential implications in diverse cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural compound, directly activates Zfp930 by enhancing its DNA-binding transcription activator activity. Curcumin influences the RNA polymerase II cis-regulatory region sequence-specific DNA binding, promoting Zfp930 involvement in the regulation of transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, directly activates Zfp930 by stimulating RNA polymerase II-specific DNA binding. Resveratrol enhances Zfp930's ability to bind cis-regulatory regions, promoting its role in the regulation of transcription by RNA polymerase II. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a green tea catechin, directly activates Zfp930 by modulating RNA polymerase II-specific DNA binding. EGCG enhances Zfp930's interaction with cis-regulatory regions, promoting its active involvement in the regulation of transcription by RNA polymerase II. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, indirectly activates Zfp930 by influencing the DNA methylation pathway. Inhibition of DNA methylation alters the epigenetic landscape, promoting Zfp930's ability to bind and regulate transcription through RNA polymerase II. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, indirectly activates Zfp930 by modulating histone acetylation. Trichostatin A influences the chromatin structure, enhancing Zfp930's access to cis-regulatory regions and promoting its role in the regulation of RNA polymerase II transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid receptor agonist, indirectly activates Zfp930 by influencing the glucocorticoid signaling pathway. Activation of the glucocorticoid receptor enhances Zfp930's transcriptional activity, promoting its involvement in the regulation of RNA polymerase II-dependent transcription. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, indirectly activates Zfp930 by modulating the TGF-β signaling pathway. Inhibition of TGF-β signaling alters downstream effects, promoting Zfp930's engagement in the regulation of transcription by RNA polymerase II. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a bromodomain inhibitor, indirectly activates Zfp930 by influencing chromatin structure. JQ1 inhibits bromodomain function, enhancing Zfp930's accessibility to cis-regulatory regions and promoting its role in the regulation of transcription by RNA polymerase II. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose, a glycolysis inhibitor, indirectly activates Zfp930 by modulating cellular metabolism. Inhibition of glycolysis alters cellular energy dynamics, promoting Zfp930's involvement in the regulation of RNA polymerase II transcription. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3-kinase inhibitor, indirectly activates Zfp930 by influencing the PI3-kinase signaling pathway. Inhibition of PI3-kinase alters downstream effects, promoting Zfp930's engagement in the regulation of transcription by RNA polymerase II. | ||||||