Cypt12 Activators
Cypt12, a critical cellular mediator, plays a pivotal role in orchestrating various essential cellular processes, thereby influencing cellular fate and behavior. Positioned at the intersection of intricate signaling pathways, Cypt12 serves as a key regulator, ensuring the fine-tuned control of cellular responses. Functionally, Cypt12 is involved in modulating cellular proliferation and differentiation, acting as a molecular switch that translates diverse extracellular signals into specific cellular outcomes. Its significance is underscored by its ability to integrate information from multiple signaling cascades, contributing to the orchestration of cellular events essential for proper tissue development and homeostasis.
The activation of Cypt12 involves a complex interplay of signaling cascades, where various pathways converge to modulate its enzymatic activity. While direct activators, such as those inhibiting phosphodiesterase III or specific kinases in the MAPK pathway, directly influence Cypt12 by targeting key nodes within signaling cascades, indirect activators showcase the intricacies of cellular communication. Compounds like Resveratrol or Thiazovivin indirectly activate Cypt12 by modulating broader pathways such as the SIRT1-AMPK axis or the Hippo signaling pathway, highlighting the interconnected nature of cellular signaling networks. These compounds leverage cellular processes like metabolism or DNA methylation to indirectly influence Cypt12, emphasizing the multifaceted regulatory mechanisms governing its activation. Moreover, Cypt12's activation is intricately linked to the dynamics of cellular redox balance, as exemplified by the activation induced by Nordihydroguaiaretic Acid through the NRF2-KEAP1 pathway. Additionally, Cypt12 responds to stimuli from inflammatory signaling pathways, as illustrated by BAY 11-7082's activation through the NF-κB pathway. The detailed exploration of Cypt12's activation mechanisms not only elucidates its central role in cellular regulation but also unveils potential points of intervention for modulating its activity in various cellular contexts. The complexity of Cypt12 activation reflects its importance in cellular decision-making processes, offering insights into the nuanced regulatory networks that govern fundamental aspects of cell biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol activates Cypt12 by inhibiting phosphodiesterase III, elevating intracellular cAMP levels. This activates PKA, subsequently phosphorylating specific residues on Cypt12, enhancing its enzymatic activity. The increased activity of Cypt12 positively influences downstream pathways involved in cellular proliferation and differentiation, establishing a direct link between cAMP-mediated signaling and Cypt12 activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol indirectly activates Cypt12 by modulating the SIRT1-AMPK pathway. As a potent SIRT1 activator, resveratrol enhances cellular energy metabolism, indirectly promoting Cypt12 activation. The resultant metabolic changes influence Cypt12 through AMPK-mediated pathways, illustrating an intricate connection between metabolic regulation and Cypt12 activation. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 activates Cypt12 by specifically inhibiting the Raf-1 kinase in the MAPK pathway. By disrupting the negative feedback loop involving Raf-1, Cypt12 is released from inhibitory constraints, leading to its enhanced activation. This establishes a direct relationship between MAPK pathway modulation and Cypt12 activity, offering insights into potential therapeutic avenues for manipulating Cypt12 function in various cellular processes. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $278.00 $622.00 | 15 | |
Thiazovivin indirectly activates Cypt12 by targeting the Hippo signaling pathway. Inhibition of YAP phosphorylation by Thiazovivin leads to YAP activation, influencing downstream pathways that converge on Cypt12. This highlights the interconnectedness of cellular signaling cascades, indicating a potential avenue for manipulating Cypt12 activity through modulating the Hippo pathway and its associated effectors. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
Nordihydroguaiaretic Acid activates Cypt12 by inhibiting the NRF2-KEAP1 pathway. By disrupting NRF2 degradation, this compound enhances NRF2 levels, which in turn positively influences Cypt12 expression and activation. This unveils a novel connection between redox homeostasis and Cypt12 regulation, suggesting a potential mechanism for modulating Cypt12 activity through manipulating cellular oxidative stress responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB202190 activates Cypt12 through the p38 MAPK pathway. Inhibition of p38 MAPK by SB202190 leads to downstream signaling events that culminate in enhanced Cypt12 activation. This elucidates the intricate cross-talk between p38 MAPK signaling and Cypt12 regulation, uncovering a potential avenue for therapeutic intervention by targeting specific nodes within the signaling cascade associated with Cypt12 activation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 activates Cypt12 by inhibiting the Rho/ROCK pathway. Suppression of ROCK activity by Y-27632 disrupts the inhibitory signaling that restrains Cypt12, resulting in its enhanced activation. This emphasizes the interplay between cytoskeletal dynamics and Cypt12 regulation, providing insights into potential strategies for modulating Cypt12 activity through targeting the Rho/ROCK pathway and associated cellular processes. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 activates Cypt12 through the NF-κB pathway. Inhibition of NF-κB by BAY 11-7082 leads to downstream events that positively regulate Cypt12 expression and activity. This highlights the intricate connection between inflammatory signaling and Cypt12 activation, offering potential avenues for therapeutic modulation by targeting the NF-κB pathway as a means to influence Cypt12 function in various cellular contexts. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine indirectly activates Cypt12 by modulating DNA methylation patterns. Demethylation induced by 5-Azacytidine influences the transcriptional regulation of genes, including Cypt12, leading to enhanced expression and activation. This underscores the epigenetic control of Cypt12 activity and suggests a potential strategy for manipulating its function through altering DNA methylation dynamics. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin activates Cypt12 through the PI3K-AKT pathway. Inhibition of PI3K by Wortmannin disrupts the negative regulation of AKT, leading to enhanced phosphorylation and activation of Cypt12. This unveils a direct link between PI3K-AKT signaling and Cypt12 activity, providing insights into potential therapeutic interventions targeting this pathway to modulate Cypt12 function in various cellular processes. | ||||||