Molecular structure of Thiazovivin, CAS Number: 1443246-62-5
Thiazovivin (CAS 1226056-71-8)
See product citations (15)
Alternate Names:
N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Application:
Thiazovivin is a ROCK inhibitor that is also known to enhance the efficiency of fibroblast reprogramming
CAS Number:
1226056-71-8
Purity:
≥98%
Molecular Weight:
311.36
Molecular Formula:
C15H13N5OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thiazovivin significantly enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells when used in combination with SB 431542 (sc-204265) and PD 0325901 (sc-205427). It is known to improve the survival of human embryonic stem cells upon trypsinization. It also behaves as an inhibitor of Rho-associated kinase (ROCK). In vitro research experiments have discovered anti-inflammatory, anti-tumor, and anti-bacterial effects of Thiazovivin. In addition, it may act to inhibit the growth of cancer cells in culture.
Thiazovivin (CAS 1226056-71-8) References
- A chemical platform for improved induction of human iPSCs. | Lin, T., et al. 2009. Nat Methods. 6: 805-8. PMID: 19838168
- Direct conversion of porcine embryonic fibroblasts into adipocytes by chemical molecules. | Zhu, J., et al. 2012. Cell Reprogram. 14: 99-105. PMID: 22372576
- Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. | Mohseni, R., et al. 2015. Cell Biol Int. 39: 515-8. PMID: 25490878
- Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. | Park, S., et al. 2015. Anim Reprod Sci. 161: 47-57. PMID: 26307658
- [Effect of a new ROCK inhibitor thiazovivin on the morphology and function of human corneal endothelial cells]. | Wu, QN., et al. 2016. Zhonghua Yan Ke Za Zhi. 52: 686-92. PMID: 27647250
- The ROCK inhibitor, thiazovivin, inhibits human corneal endothelial‑to‑mesenchymal transition/epithelial‑to‑mesenchymal transition and increases ionic transporter expression. | Wu, Q., et al. 2017. Int J Mol Med. 40: 1009-1018. PMID: 28849097
- Derivation and characterization of the NYSCFe003-A human embryonic stem cell line. | Sevilla, A., et al. 2017. Stem Cell Res. 25: 217-220. PMID: 29161648
- Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer. | Gao, L., et al. 2019. Front Cell Neurosci. 13: 316. PMID: 31327963
- The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells. | Krewson, EA., et al. 2020. iScience. 23: 100848. PMID: 32058960
- Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes. | Kleinsorge, M. and Cyganek, L. 2020. STAR Protoc. 1: 100026. PMID: 33111079
- Human Induced Pluripotent Stem Cell (iPSC) Handling Protocols: Maintenance, Expansion, and Cryopreservation. | Marotta, D., et al. 2022. Methods Mol Biol. 2454: 1-15. PMID: 33837517
- Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells. | Lewis-Israeli, YR., et al. 2021. J Vis Exp.. PMID: 34605811
- Human Induced Pluripotent Stem Cell-Derived Microglia (hiPSC-Microglia). | McQuade, A. and Blurton-Jones, M. 2022. Methods Mol Biol. 2454: 473-482. PMID: 34773245
- S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia. | Oh, CK., et al. 2022. J Neurosci. 42: 3011-3024. PMID: 35169022
- ROCK1/MLC2 inhibition induces decay of viral mRNA in BPXV infected cells. | Kumar, R., et al. 2022. Sci Rep. 12: 17811. PMID: 36280692
Inhibitor of:
4930412D23Rik, ACSL, ACSL4, ACSVL4, ACSVL5, C20orf95, C6orf100, DAAM2, Ect2, EG432555, EG435927, ESC, FMNL3, FRMD3, FRMD5, Gα t2, GNGT2, HIP-55, JMY, KCC2a, LOC635396, M-RIP, MRLC2, MRVI1, MYH4, MYH9, MYL6, MYPT2, NET1, Neuro D, Nogo-R, Oct-3A, Pinch-3, PITHD1, PLEK2, PPDPF, RGMb, Rho A, Rock, SERTAD3, SIRT7, SPARCL1_Sc1, STARS, Synaptotagmin II, TBX5, and WDR24.Activator of:
4930428D18Rik, cadherin-22, CD34, Cdc45, CHRDL1, Cypt12, DAF-1, Dkk-4, FLRG, Miz-1, MOB1B, Myosin VI, MYT1, Nanog, nephrocystin, Oct-3/4, Rho B, Sox-2, SSEA-4, TRA-1-81, VWC2, ZIP-kinase, and ZNF595.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiazovivin, 10 mg | sc-361380 | 10 mg | $278.00 | |||
Thiazovivin, 25 mg | sc-361380A | 25 mg | $622.00 |