CYP2D12 Inhibitors
CYP2D12, a member of the cytochrome P450 enzyme family, is predicted to play a pivotal role in heme binding and monooxygenase activities, with involvement in arachidonic acid metabolic processes and xenobiotic metabolic processes. Located in the mitochondrion and active in the cytoplasm and intracellular membrane-bounded organelles, this enzyme is implicated in diseases such as acute lymphoblastic leukemia, acute myeloid leukemia, asthma, autoimmune hepatitis, and rhinitis.
Inhibitors of CYP2D12, whether direct or indirect, offer a diverse range of chemicals that modulate its activities. These inhibitors interfere with monooxygenase activity, alter mitochondrial and cytoplasmic dynamics, and hinder the enzyme's predicted participation in xenobiotic metabolic processes. The identification of CYP2D12 inhibitors provides insights into potential mechanisms for regulating its functions, contributing to a broader understanding of cellular processes and their implications in health and disease. Further research into these inhibitors could open avenues for research and advancements in our understanding of cellular metabolism.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Antifungal agent in research acting as a direct inhibitor of CYP2D12 by interfering with monooxygenase activity. Modifies mitochondrial and cytoplasmic dynamics, hindering the enzyme's predicted involvement in xenobiotic metabolic processes. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Antifungal agent in research indirectly impacting CYP2D12 by suppressing monooxygenase activity. Influences intracellular membrane dynamics, hindering the enzyme's predicted involvement in xenobiotic metabolic processes. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
H2 receptor antagonist acting as a direct inhibitor of CYP2D12 by interfering with monooxygenase activity. Alters cytoplasmic dynamics and intracellular membrane-bounded organelle functions, hindering the enzyme's predicted involvement in arachidonic acid metabolic processes. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
Antifungal agent in research acting as a direct inhibitor of CYP2D12 by interfering with monooxygenase activity. Modifies mitochondrial and cytoplasmic dynamics, hindering the enzyme's predicted participation in xenobiotic metabolic processes. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $122.00 | 7 | |
Antiretroviral agent in research acting as a direct inhibitor of CYP2D12 by interfering with monooxygenase activity. Modifies mitochondrial and intracellular membrane-bounded organelle functions, hindering the enzyme's predicted involvement in xenobiotic metabolic processes. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Macrolide antibiotic acting as a direct inhibitor of CYP2D12 by interfering with monooxygenase activity. Alters mitochondrial and cytoplasmic dynamics, hindering the enzyme's predicted involvement in xenobiotic metabolic processes. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Antimalarial agent in research directly inhibiting CYP2D12 by interfering with monooxygenase activity. Modifies cytoplasmic and intracellular membrane dynamics, hindering the enzyme's predicted participation in heme binding processes. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Calcium channel blocker acting as a direct inhibitor of CYP2D12 by interfering with monooxygenase activity. Modifies mitochondrial and intracellular membrane-bounded organelle functions, hindering the enzyme's predicted involvement in arachidonic acid metabolic processes. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Calcium channel blocker acting as a direct inhibitor of CYP2D12 by interfering with monooxygenase activity. Alters mitochondrial and cytoplasmic dynamics, hindering the enzyme's predicted participation in arachidonic acid metabolic processes. | ||||||
Ranitidine | 66357-35-5 | sc-203679 | 1 g | $189.00 | ||
H2 receptor antagonist acting as a direct inhibitor of CYP2D12 by interfering with monooxygenase activity. Modifies cytoplasmic and intracellular membrane dynamics, hindering the enzyme's predicted involvement in arachidonic acid metabolic processes. | ||||||