Molecular structure of Cimetidine, CAS Number: 51481-61-9
Cimetidine (CAS 51481-61-9)
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Alternate Names:
Tagamet; SKF-92334; Tratul; Tametin; Dyspamet; Acinil; 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine
Application:
Cimetidine is an inhibitor of histamine binding to histamine H2 receptors
CAS Number:
51481-61-9
Purity:
≥99%
Molecular Weight:
252.34
Molecular Formula:
C10H16N6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cimetidine is an immunomodulator and a histamine congener. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent. Cimetidine is an activator of Nischarin.
Cimetidine (CAS 51481-61-9) References
- Cimetidine in painful bladder syndrome: a histopathological study. | Dasgupta, P., et al. 2001. BJU Int. 88: 183-6. PMID: 11488726
- Physicochemical properties of amorphous salt of cimetidine and diflunisal system. | Yamamura, S., et al. 2002. Int J Pharm. 241: 213-21. PMID: 12100849
- Photochemical fate of pharmaceuticals in the environment: cimetidine and ranitidine. | Latch, DE., et al. 2003. Environ Sci Technol. 37: 3342-50. PMID: 12966980
- Floating microspheres of cimetidine: formulation, characterization and in vitro evaluation. | Srivastava, AK., et al. 2005. Acta Pharm. 55: 277-85. PMID: 16375838
- Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity. | Katsuda, H., et al. 2010. Biol Pharm Bull. 33: 1867-71. PMID: 21048313
- Distribution, properties, and functional characteristics of three classes of histamine receptor. | Hill, SJ. 1990. Pharmacol Rev. 42: 45-83. PMID: 2164693
- Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases. | Jafarzadeh, A., et al. 2019. Int Immunopharmacol. 70: 156-166. PMID: 30802678
- The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon. | Oberle, RL. and Amidon, GL. 1987. J Pharmacokinet Biopharm. 15: 529-44. PMID: 3694496
- Effect of cimetidine and other antihistaminics on the elimination of aminopyrine, phenacetin and caffeine. | Desmond, PV., et al. 1980. Life Sci. 26: 1261-8. PMID: 6104763
- Successful tumour immunotherapy with cimetidine in mice. | Osband, ME., et al. 1981. Lancet. 1: 636-8. PMID: 6110864
- Cimetidine as an immunomodulator: chronic mucocutaneous candidiasis as a model. | Jorizzo, JL., et al. 1980. Ann Intern Med. 92: 192-5. PMID: 7352725
- Why imidazoline receptor modulator in the treatment of hypertension? | Schäfer, SG., et al. 1995. Ann N Y Acad Sci. 763: 659-72. PMID: 7677385
- The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans. | Tsoli, E., et al. 1995. Eur J Pharmacol. 284: 199-203. PMID: 8549627
- Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. | Smit, MJ., et al. 1996. Proc Natl Acad Sci U S A. 93: 6802-7. PMID: 8692899
Inhibitor of:
5 alpha-Reductase 2, ADH, ADHβ, ASC2, BC014805, BOCT, BOULE, CIDE-A, CTGLF, CTGLF7, CTL3, CYP1A2, CYP20A1, CYP27B1, CYP2AB1, CYP2C19, Cyp2c38, Cyp2c39, Cyp2c65, Cyp2c66, Cyp2c69, CYP2D12, CYP2D40, CYP2E1, CYP2F1, CYP2S1, CYP2U1, CYP39A1, CYP3A1, Cyp3a11, Cyp3a13, Cyp3a18, Cyp3a25, Cyp3a41a, CYP3A43, Cyp3a44, Cyp3a57, Cyp3a59, CYP3A7-CYP3AP1, CYP4B1, CYP4F3, CYP4V2, CYP4Z1, Cyp60, CyPA, cytochrome b5 type B, EG226604, EG625716, FK-506, FMO4, FMO5, FMO6, Gastrin, Gastrokine 1, Gastrokine 3, GIF, GPR87, H2-Adβ, H2-I, H2RSP, HDC, Histamine H2 Receptor, HNMT, HRT2, ISX, KA2, LOC729083, MATE1, OAT3, OAT6, OATP-A, Oct-2, Olfr10, Olfr1000, Olfr1018, Olfr1032, Olfr1056, Olfr374, Olfr380, Olfr392, Olfr509, Olfr666, Olfr726, Olfr727, Olfr728, Olfr821, Olfr822, Olfr829, Olfr94, Olr1111, Olr208, OR5K1, PELO, Pepsin A, Pepsin A4, Pepsin C, Pepsinogen A, PIMT, RT1-Bβ, SIMP, SLC22A11, SLC22A14, SLC22A15, Slc22a22, SLC22A23, SLC22A24, SLC22A29, SLC22A9, SMR3A, ST8Sia V, Tas2r125, Transcobalamin I, Vmn1r101, Vmn1r15, Vmn1r17, Vmn1r184, Vmn1r196, Vmn1r221, Vmn1r30, Vmn1r34, Vmn1r61, Vmn1r86, Vmn1r88, Vmn2r103, and Vmn2r40.Activator of:
BC014805, CCK, CD92, Chemokine Receptor D6, CYP2AB1, CYP2D11, Doxl2, FMO1, FMO2, FMO3, GnRH I, Histamine, Nischarin, OCTN1, ORCTL2, SLC10A5, Slc22a22, SLC25A21, SLC35E4, SLC45A4, and SLC46A3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cimetidine, 5 g | sc-202996 | 5 g | $62.00 | |||
Cimetidine, 10 g | sc-202996A | 10 g | $86.00 |