CYP2D12 Inhibitors

CYP2D12, a member of the cytochrome P450 enzyme family, is predicted to play a pivotal role in heme binding and monooxygenase activities, with involvement in arachidonic acid metabolic processes and xenobiotic metabolic processes. Located in the mitochondrion and active in the cytoplasm and intracellular membrane-bounded organelles, this enzyme is implicated in diseases such as acute lymphoblastic leukemia, acute myeloid leukemia, asthma, autoimmune hepatitis, and rhinitis.

Inhibitors of CYP2D12, whether direct or indirect, offer a diverse range of chemicals that modulate its activities. These inhibitors interfere with monooxygenase activity, alter mitochondrial and cytoplasmic dynamics, and hinder the enzyme's predicted participation in xenobiotic metabolic processes. The identification of CYP2D12 inhibitors provides insights into potential mechanisms for regulating its functions, contributing to a broader understanding of cellular processes and their implications in health and disease. Further research into these inhibitors could open avenues for research and advancements in our understanding of cellular metabolism.