Molecular structure of Quinine, CAS Number: 130-95-0
Quinine (CAS 130-95-0)
See product citations (1)
Alternate Names:
(8α,9R)-6-Methoxycinchonan-9-ol
Application:
Quinine is an antimalarial
CAS Number:
130-95-0
Molecular Weight:
324.42
Molecular Formula:
C20H24N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant.Its mechanisms of action are diverse, including the reduction of oxygen intake, interference with carbohydrate metabolism, disruption of DNA replication and transcription via DNA intercalation, and modulation of muscle fiber excitability through calcium distribution alteration. Additionally, quinine inhibits the drug efflux pump P-glycoprotein, potentially enhancing the efficacy of certain antineoplastic agents.In chemical terms, quinine, also known as chinin or (8S, 9R)-quinine, falls into the class of cinchona alkaloids. These alkaloids are characterized by the cinchonan skeleton, which consists of a quinoline linked to an azabicyclo[2.2.2]octane moiety. Quinine is most encountered as a solid, practically insoluble in water, and relatively neutral in nature.
Quinine (CAS 130-95-0) References
- Quinine blocks specific gap junction channel subtypes. | Srinivas, M., et al. 2001. Proc Natl Acad Sci U S A. 98: 10942-7. PMID: 11535816
- Systemic quinine photosensitivity with photoepicutaneous cross-reactivity to quinidine. | Ljunggren, B., et al. 1992. Contact Dermatitis. 26: 1-4. PMID: 1600732
- Quinine substitutes in the confederate army. | Hasegawa, GR. 2007. Mil Med. 172: 650-5. PMID: 17615851
- Pharmacokinetics of quinine in young and elderly subjects. | Wanwimolruk, S., et al. 1991. Trans R Soc Trop Med Hyg. 85: 714-7. PMID: 1801332
- Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. | Achan, J., et al. 2011. Malar J. 10: 144. PMID: 21609473
- Asymmetric synthesis of (+)-mequitazine from quinine. | Leroux, S., et al. 2011. Org Lett. 13: 3549-51. PMID: 21657243
- Efficacy of quinine against ichthyophthiriasis in common carp Cyprinus carpio. | Schumacher, IV., et al. 2011. Dis Aquat Organ. 95: 217-24. PMID: 21932533
- [Therapeutic drug monitoring of quinine]. | Verdier, MC., et al. 2011. Therapie. 66: 507-16. PMID: 22186076
- Analytics of Quinine and its Derivatives. | Kluska, M., et al. 2016. Crit Rev Anal Chem. 46: 139-45. PMID: 25831406
- Investigation of the quinine sulfate dihydrate spectral properties and its effects on Cherenkov dosimetry. | Jean, E., et al. 2019. Phys Med Biol. 64: 155019. PMID: 31181556
- Antimalarial Natural Products. | Kingston, DGI. and Cassera, MB. 2022. Prog Chem Org Nat Prod. 117: 1-106. PMID: 34977998
- Quinine and quinidine photoproducts can be identical. | Isaksson, M., et al. 1994. Acta Derm Venereol. 74: 286-8. PMID: 7976088
- The reproducibility of quinine bioavailability. | Paintaud, G., et al. 1993. Br J Clin Pharmacol. 35: 305-7. PMID: 8471408
Inhibitor of:
ANKRD61, CNG-1β, CNG-4, Cngb1, connexin 23, connexin 25, connexin 26, connexin 29, connexin 31, connexin 32, connexin 36, connexin 39, connexin 40.1, Connexin 43, connexin 45, connexin 46, connexin 47, connexin 59, CYP2D12, CYP2D40, DFNB59, EG226601, FLVCR, GPR89, HRP-2, KCNV1, KV3.2, LHFPL5, LRRC8E, MFSD9, MIP-T3, Mmgt2, OCT, ODR4, Olfr16, Olfr315, Olfr320, Olfr33, Olfr331, Olfr332, Olfr338, Olfr345, Olfr347, Olfr348, Olfr351, Olfr352, Olfr356, Olfr358, Olfr508, Olfr57, Olfr654, Olfr656, Olfr729, Olfr730, Olfr731, Olfr799, Olfr855, Olfr857, OR2AP1, OR2J2, OR2T34, OR2W3, OR5H14, OR5H15, OR5K2, OR5M8, OR5V1, OR6C1, OR6C6, OR6C65, OR6C68, OR6C74, OR6C76, OTOP1, P. falciparum infected RBCs, Pannexin-2, Plasmodium falciparum, Prestin, Rhodopsin, Slc22a22, SLC41A2, Slc4a11, Stereocilin, SULT2A6, SUR-1, T2R05, T2R09, T2R13, T2R14, T2R23, T2R24, T2R26, T2R42, T2R48, T2R9, TALK-1, TALK-2, TAS1R (taste receptor; GPCR), TAX-4, THIK-2, TMC2, TMEM175, TMIE, Trcg1, TWIK-2, TWIK-3, V1RH1, Vmn2r100, Vmn2r103, Vmn2r106, Vmn2r107, Vmn2r2, Vmn2r20, Vmn2r24, Vmn2r31, Vmn2r4, Vmn2r40, Vmn2r41, Vmn2r90, Vmn2r95, Vmn2r99, and VSV-G.Activator of:
ASIC-β, BC014805, connexin 30, connexin 30.3, connexin 31.1, connexin 39, connexin 46, connexin 50, KCNH3, KCNH4, KCNRG, KV1.3, motilin, MRGX4, ODR4, Olfr1008, Olfr1110, Olfr1111, Olfr1112, Olfr1113, Olfr1115, Olfr1116, Olfr1118, Olfr112, Olfr1120, Olfr1121, Olfr1122, Olfr1123, Olfr1125, Olfr1126, Olfr1128, Olfr1129, Olfr113, Olfr1130, Olfr1131, Olfr1132, Olfr1133, Olfr1134, Olfr1135, Olfr1136, Olfr1137, Olfr1138, Olfr114, Olfr1140, Olfr1141, Olfr1143, Olfr1145, Olfr1148, Olfr115, Olfr1151, Olfr1152, Olfr1153, Olfr1154, Olfr1155, Olfr1156, Olfr1157, Olfr1158, Olfr116, Olfr1160, Olfr1161, Olfr1162, Olfr1163, Olfr1164, Olfr1167, Olfr1168, Olfr117, Olfr1170, Olfr1173, Olfr1176, Olfr1179, Olfr118, Olfr1180, Olfr1181, Olfr1182, Olfr1183, Olfr1184, Olfr1186, Olfr1188, Olfr1189, Olfr119, Olfr1193, Olfr1195, Olfr1196, Olfr1197, Olfr1198, Olfr1199, Olfr12, Olfr120, Olfr1200, Olfr1201, Olfr1202, Olfr1203, Olfr1204, Olfr1206, Olfr1208, Olfr1209, Olfr121, Olfr1211, Olfr1212, Olfr1213, Olfr1214, Olfr1215, Olfr1216, Olfr1217, Olfr1218, Olfr1219, Olfr122, Olfr1220, Olfr1221, Olfr1222, Olfr1223, Olfr1225, Olfr1226, Olfr1228, Olfr1229, Olfr123, Olfr1230, Olfr1231, Olfr1232, Olfr1233, Olfr1234, Olfr1238, Olfr1239, Olfr124, Olfr1240, Olfr1241, Olfr1242, Olfr1243, Olfr1245, Olfr1246, Olfr1247, Olfr1248, Olfr1249, Olfr125, Olfr1250, Olfr1251, Olfr1252, Olfr1254, Olfr1255, Olfr1256, Olfr1257, Olfr1258, Olfr1259, Olfr126, Olfr1260, Olfr1261, Olfr1262, Olfr1263, Olfr1264, Olfr1265, Olfr1269, Olfr127, Olfr1270, Olfr1271, Olfr1272, Olfr1273, Olfr1275, Olfr1276, Olfr1277, Olfr1278, Olfr1279, Olfr128, Olfr1280, Olfr1281, Olfr1282, Olfr1283, Olfr1284, Olfr1285, Olfr1286, Olfr1287, Olfr1289, Olfr129, Olfr1290, Olfr1294, Olfr1295, Olfr1297, Olfr1298, Olfr1299, Olfr13, Olfr130, Olfr1301, Olfr1302, Olfr1303, Olfr1305, Olfr1306, Olfr1307, Olfr1308, Olfr1309, Olfr131, Olfr1310, Olfr1311, Olfr1312, Olfr1313, Olfr1314, Olfr1316, Olfr1317, Olfr1318, Olfr132, Olfr1320, Olfr1321, Olfr1322, Olfr1323, Olfr1324, Olfr1325, Olfr1329, Olfr133, Olfr1330, Olfr1331, Olfr1333, Olfr1335, Olfr1336, Olfr1337, Olfr1338, Olfr1339, Olfr134, Olfr1340, Olfr1341, Olfr1342, Olfr1344, Olfr1346, Olfr1347, Olfr1348, Olfr1349, Olfr135, Olfr1350, Olfr1351, Olfr1352, Olfr1353, Olfr1355, Olfr1356, Olfr1357, Olfr1358, Olfr1359, Olfr136, Olfr1360, Olfr1361, Olfr1362, Olfr1364, Olfr1365, Olfr1366, Olfr1367, Olfr1368, Olfr137, Olfr1370, Olfr1371, Olfr1373, Olfr1377, Olfr1378, Olfr138, Olfr1380, Olfr1381, Olfr1382, Olfr1383, Olfr1384, Olfr1385, Olfr1386, Olfr1387, Olfr1388, Olfr1389, Olfr139, Olfr1390, Olfr1391, Olfr1392, Olfr1393, Olfr1394, Olfr1395, Olfr1396, Olfr140, Olfr1402, Olfr1403, Olfr1404, Olfr1406, Olfr1408, Olfr141, Olfr1410, Olfr1411, Olfr1412, Olfr1413, Olfr1414, Olfr1415, Olfr1416, Olfr1417, Olfr1418, Olfr1419, Olfr142, Olfr1420, Olfr1423, Olfr1424, Olfr1425, Olfr1427, Olfr1428, Olfr143, Olfr1431, Olfr1433, Olfr1436, Olfr1437, Olfr144, Olfr1440, Olfr1441, Olfr1442, Olfr1443, Olfr1444, Olfr1445, Olfr1446, Olfr1447, Olfr1448, Olfr1449, Olfr145, Olfr1450, Olfr1451, Olfr1453, Olfr1454, Olfr1457, Olfr1459, Olfr146, Olfr1461, Olfr1462, Olfr1463, Olfr1465, Olfr1466, Olfr1467, Olfr1469, Olfr147, Olfr1471, Olfr1472, Olfr1474, Olfr1475, Olfr1477, Olfr148, Olfr1480, Olfr1484, Olfr1487, Olfr1489, Olfr149, Olfr1490, Olfr1491, Olfr1494, Olfr1495, Olfr1496, Olfr1497, Olfr1499, Olfr150, Olfr1500, Olfr1501, Olfr1502, Olfr1504, Olfr1505, Olfr1506, Olfr1508, Olfr1509, Olfr1510, Olfr1511, Olfr1512, Olfr1513, Olfr1518, Olfr1519, Olfr152, Olfr153, Olfr154, Olfr155, Olfr156, Olfr159, Olfr160, Olfr161, Olfr164, Olfr165, Olfr166, Olfr167, Olfr168, Olfr169, Olfr17, Olfr170, Olfr171, Olfr172, Olfr173, Olfr174, Olfr178, Olfr18, Olfr180, Olfr181, Olfr183, Olfr186, Olfr187, Olfr19, Olfr190, Olfr191, Olfr192, Olfr193, Olfr194, Olfr195, Olfr196, Olfr197, Olfr198, Olfr199, Olfr2, Olfr20, Olfr201, Olfr202, Olfr203, Olfr204, Olfr205, Olfr206, Olfr207, Olfr211, Olfr212, Olfr213, Olfr214, Olfr215, Olfr216, Olfr218, Olfr220, Olfr221, Olfr222, Olfr223, Olfr225, Olfr228, Olfr23, Olfr234, Olfr235, Olfr24, Olfr242, Olfr244, Olfr247, Olfr25, Olfr259, Olfr26, Olfr262, Olfr266, Olfr267, Olfr27, Olfr270, Olfr272, Olfr273, Olfr275, Olfr281, Olfr282, Olfr283, Olfr284, Olfr285, Olfr286, Olfr287, Olfr288, Olfr290, Olfr291, Olfr292, Olfr293, Olfr294, Olfr295, OR2V1, OTOP1, OTOP3, Slo3, T2R04, T2R05, T2R06, T2R1, T2R10, T2R13, T2R134, T2R14, T2R15, T2R16, T2R17, T2R18, T2R20, T2R21, T2R22, T2R23, T2R24, T2R3, T2R37, T2R39, T2R4, T2R40, T2R43, T2R44, T2R45, T2R46, T2R47, T2R48, T2R49, T2R50, T2R6, T2R60, T2R7, T2R8, T2R9, Tas2r102, Tas2r114, Tas2r125, Tas2r140, Tas2r143, TASK-5, TMC1, TRPM5, TWIK-3, and V1RL5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Quinine, 1 g | sc-212616 | 1 g | $77.00 | |||
Quinine, 5 g | sc-212616A | 5 g | $102.00 | |||
Quinine, 10 g | sc-212616B | 10 g | $163.00 | |||
Quinine, 25 g | sc-212616C | 25 g | $347.00 | |||
Quinine, 50 g | sc-212616D | 50 g | $561.00 |