cyclin O Activators
Cyclin O activators are chemical compounds that indirectly enhance the functional activity of cyclin O through diverse signaling pathways. Forskolin and Rolipram both elevate intracellular cAMP levels, with Forskolin directly activating adenylate cyclase and Rolipram inhibiting cAMP breakdown by phosphodiesterase 4. This accumulation of cAMP activates PKA, which has the potential to phosphorylate proteins within the signaling network that cyclin O operates in, thus enhancing its role in cell cycle regulation. Ionomycin raises intracellular calcium levels, which might affect signaling pathways that cyclin O is involved in due to its impact on calcium-dependent processes. TPA and Gö6976 both act on PKC, with TPA being an activator and Gö6976 a selective inhibitor, but their influence on downstream pathways could lead to an enhanced activity of cyclin O in cell proliferation and signaling.
Continuing with molecules that can influence the activity of cyclin O, Okadaic acid and Calyculin A prevent the dephosphorylation of proteins by inhibiting protein phosphatases 1 and 2A, potentially causing an increase in the phosphorylation state of cyclin O's interacting proteins, leading to its indirect activation. Inhibitors like PD 98059, LY294002, and SB203580 target key enzymes in the MAPK/ERK and PI3K/AKT pathways, respectively, which are critical in cell cycle progression and may, therefore, fine-tune the cellular environment to favor cyclin O activity. Similarly, KN-93 and ZM 447439, by targeting CaMKII and Aurora kinases, respectively, mayalter the phosphorylation dynamics of key regulators in cell cycle pathways, offering an indirect mechanism to augment cyclin O's functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate substrates that may interact with cyclin O, enhancing its role in cell cycle regulation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing cAMP breakdown, which indirectly supports the cAMP/PKA signaling pathway. This can enhance the activity of cyclin O by maintaining a cellular environment that favors its functional role. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially affecting cell cycle progression and cyclin O activity by modifying calcium-dependent signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, which could lead to enhanced phosphorylation states of proteins within pathways that cyclin O is a part of, thus indirectly increasing its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, like okadaic acid, is an inhibitor of protein phosphatases, leading to an increase in phosphorylation of proteins that could interact with cyclin O, promoting its activity indirectly. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a MEK inhibitor that might affect the MAPK/ERK pathway, which can have downstream effects on the cell cycle and potentially enhance the activity of cyclin O. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that may alter the AKT pathway and influence cell cycle progression, which could lead to the indirect activation of cyclin O. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, which can shift signaling pathways to favor those that interact with or activate cyclin O, thereby enhancing its function. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a CaMKII inhibitor. By selectively blocking CaMKII, it can influence cell cycle-related pathways and indirectly lead to the activation of cyclin O. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM 447439 is an Aurora kinase inhibitor that could affect the phosphorylation of substrates vital for cell cycle progression, potentially enhancing the role of cyclin O in this process. | ||||||