CUL-4B Activators
CUL-4B Activators are a diverse group of chemicals that indirectly influence the activity of the CUL-4B protein by modulating various cellular signaling pathways. These activators encompass a wide range of compounds, each with unique properties and mechanisms of action, targeting different aspects of cellular function. The primary characteristic of CUL-4B Activators is their ability to interact with and influence key signaling pathways that are indirectly related to the regulation and function of CUL-4B. For example, compounds like Sulforaphane and Curcumin affect the Nrf2 and NF-κB pathways, respectively. These pathways play roles in oxidative stress responses and inflammation, which are crucial for cellular homeostasis and can indirectly influence the activity of proteins involved in DNA repair and cell cycle regulation, including CUL-4B.
Similarly, compounds like Resveratrol and EGCG target pathways related to aging, stress response, and cell survival, such as the SIRT1 and PI3K/AKT/mTOR pathways. By modulating these pathways, they can indirectly impact the function or expression of CUL-4B in cells. Another key aspect of CUL-4B Activators is their potential to modulate multiple signaling pathways, thereby exerting a broader influence on cellular processes. This multiplicity of action is exemplified by compounds like Metformin and Rapamycin, which target energy homeostasis and cell growth pathways, respectively. Such broad-spectrum effects can lead to complex interactions within cellular signaling networks, potentially affecting the regulation of CUL-4B in various contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a compound found in cruciferous vegetables, can modulate the Nrf2 pathway. By activating Nrf2, it leads to the upregulation of antioxidant response elements, which may influence CUL-4B activity indirectly through oxidative stress-related pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, the active component of turmeric, affects the NF-κB pathway. It can modulate inflammatory responses, potentially altering CUL-4B activity or expression through this pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in grapes, influences SIRT1 activation. By modulating SIRT1, it can affect pathways related to aging and stress response, potentially impacting CUL-4B activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a component of green tea, has been shown to affect the PI3K/AKT/mTOR pathway. This pathway is crucial for cell survival and growth, potentially influencing CUL-4B activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, modulates the JAK/STAT pathway. This can influence various cellular processes, including those related to inflammation and immune responses, potentially affecting CUL-4B. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000 sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E | 1 g 5 g 10 g 50 g 100 g 250 g | $30.00 $42.00 $62.00 $153.00 $255.00 $500.00 | 37 | |
Metformin, commonly used for type 2 diabetes, influences AMPK activation. Through AMPK, it can modulate energy homeostasis pathways, potentially impacting CUL-4B activity. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 modulates several signaling pathways, including those involved in cell growth and immune responses. Its influence on these pathways can indirectly affect CUL-4B activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, found in Vitamin A, affects cellular differentiation and growth through the retinoic acid receptor. This can influence CUL-4B activity in pathways related to cell cycle and development. | ||||||
Pioglitazone hydrochloride | 112529-15-4 | sc-204848 sc-204848A | 100 mg 500 mg | $62.00 $209.00 | 19 | |
Pioglitazone, a PPAR-γ agonist, influences pathways related to glucose metabolism and adipocyte differentiation, potentially impacting CUL-4B activity. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol, found in cruciferous vegetables, modulates estrogen metabolism pathways, which can indirectly affect CUL-4B activity. | ||||||