CUL-4B Inhibitors
CUL-4B Inhibitors are a varied group of chemicals that can indirectly suppress the activity of the CUL-4B protein by interacting with and influencing key cellular signaling pathways and processes. These inhibitors have distinct modes of action, each targeting various aspects of cellular function that can impact the regulation and activity of CUL-4B.
A key feature of CUL-4B Inhibitors is their capacity to interact with specific signaling pathways and cellular processes, thereby exerting an indirect inhibitory effect on CUL-4B. For example, proteasome inhibitors like Bortezomib and MG132 disrupt protein degradation pathways, a process in which CUL-4B is critically involved. By impacting the ubiquitin-proteasome system, these compounds can indirectly inhibit CUL-4B's function in protein turnover. Similarly, kinase inhibitors such as Sorafenib and Dasatinib, with their broad-spectrum inhibitory actions, can affect multiple signaling pathways, including those in which CUL-4B plays a role, thereby indirectly suppressing its activity. Another important aspect of these inhibitors is their potential to modulate transcriptional and post-transcriptional processes that are integral to CUL-4B's function. Compounds like Trichostatin A and U0126, which influence gene expression and MAPK/ERK signaling respectively, can indirectly inhibit CUL-4B by altering the cellular environment and signaling context in which CUL-4B operates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib, a proteasome inhibitor, can disrupt protein degradation pathways, potentially affecting the stability and function of CUL-4B as it plays a role in ubiquitin-mediated degradation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132, another proteasome inhibitor, similarly affects protein degradation pathways. It may influence CUL-4B activity by altering the ubiquitin-proteasome system. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Sirolimus, an mTOR inhibitor, affects cell growth and proliferation pathways. Its impact on these pathways can indirectly inhibit CUL-4B activity, given the protein's role in cell cycle regulation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3, a MDM2 inhibitor, stabilizes p53 by preventing its MDM2-mediated degradation. Given CUL-4B's involvement in cell cycle regulation, p53 stabilization can indirectly inhibit CUL-4B activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, affects the AKT signaling pathway. By influencing this pathway, it can indirectly inhibit CUL-4B, which is involved in various cell signaling processes. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib, a kinase inhibitor, targets multiple kinases including RAF, VEGFR, and PDGFR. Its broad-spectrum action can indirectly affect CUL-4B activity through various signaling pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, affects gene expression. By altering transcriptional regulation, it may indirectly inhibit CUL-4B activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib, a broad-spectrum tyrosine kinase inhibitor, affects multiple pathways including Src family kinases and BCR-ABL. It can indirectly inhibit CUL-4B activity through these pathways. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, a PARP inhibitor, is involved in DNA repair mechanisms. By influencing DNA repair pathways, it may indirectly affect CUL-4B's role in these processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059, a MEK inhibitor, specifically targets the MAPK/ERK pathway. This can lead to indirect inhibition of CUL-4B, which is involved in cell signaling. | ||||||