CTAGE5 Activators
CTAGE5 Activators are a collection of chemical compounds designed to indirectly enhance the functional activity of CTAGE5 through specific intracellular signaling pathways. Forskolin and Isoproterenol elevate cAMP, which in turn activates PKA, a kinase that could directly phosphorylate CTAGE5, thus enhancing its role in intracellular transport. PMA, as a PKC activator, may also phosphorylate CTAGE5 or associated proteins, promoting its function in vesicle transport. Similarly, calcium ionophores like Ionomycin and A23187 increase intracellular calcium concentrations, potentially affecting calcium-dependent signaling pathways that could indirectly enhance CTAGE5's activity within the endoplasmic reticulum-export system. IBMX, by inhibiting the breakdown of cAMP, and Dibutyryl-cAMP, a cAMP analog, serve to sustain and mimic PKA activity, respectively, which could lead to enhanced phosphorylation and activation of CTAGE5.
In the same vein, LY294002 and Genistein manipulate PI3K and tyrosine kinase pathways, altering downstream signaling that favors CTAGE5 activity in vesicle formation and trafficking. U0126, by inhibiting MEK1/2, shifts signaling equilibriums that could indirectly favor CTAGE5's role in vesicle transport. Sphingosine-1-phosphate may also promote cytoskeletal rearrangements that support CTAGE5's function in the secretory pathway. Lastly, EGCG, through its kinase inhibitory effects, may reduce competitive signaling, indirectly allowing CTAGE5 to play a more prominent role in its specific processes within the cell. Collectively, these compounds act on a molecular level to enhance the functional activity of CTAGE5 through a variety of signaling pathways and cellular processes without directly increasing its expression or requiring direct activation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly elevates intracellular cAMP levels, which can lead to the activation of PKA. PKA can phosphorylate proteins including CTAGE5, potentially enhancing its function in processes such as intracellular transport. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as a PKC activator, which is known to phosphorylate a multitude of proteins. Phosphorylation by PKC can enhance the activity of CTAGE5 by promoting its interaction with other proteins involved in vesicle transport. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, indirectly enhancing the activity of calcium-dependent proteins that could upregulate CTAGE5 activity in the endoplasmic reticulum-export system. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that elevates cAMP levels, similarly to forskolin, potentially leading to enhanced CTAGE5 activity through PKA-mediated pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP, thereby potentially increasing PKA activity and subsequent phosphorylation that could enhance CTAGE5 function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit certain kinases, potentially reducing competitive signaling and indirectly enhancing CTAGE5 activity by altering protein interactions within the vesicle transport system. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore, promoting the increase of intracellular calcium levels which could activate calcium-binding proteins indirectly increasing CTAGE5 activity in related signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter signaling pathways leading to activation of downstream proteins, potentially enhancing the activity of CTAGE5 through altered vesicle formation and trafficking. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is involved in signaling pathways that can lead to cytoskeletal rearrangements and impact vesicle trafficking, potentially enhancing CTAGE5 function in the secretory pathway. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that can permeate cell membranes and directly activate PKA, potentially leading to enhanced CTAGE5 activity by influencing its role in vesicle formation and trafficking. | ||||||