CTAGE2 Inhibitors
Chemical inhibitors of CTAGE2 can disrupt its function through various mechanisms related to cell cycle regulation and proteasomal activity. Alisertib, ZM447439, and Volasertib target and inhibit Aurora kinases, which are essential regulators of mitosis. The inhibition of these kinases by these chemicals can arrest the cell cycle, potentially leading to an inhibition of CTAGE2. Similarly, Paclitaxel (Taxol) stabilizes microtubules and prevents their disassembly, which is also crucial for mitosis. This action can obstruct the function of CTAGE2. Monastrol and S-Trityl-L-cysteine specifically inhibit the kinesin Eg5, leading to defects in spindle bipolarity, which would be detrimental to CTAGE2 function.
Additionally, proteasome inhibitors like Marizomib, Bortezomib, and MG132 can impede CTAGE2 by preventing the degradation of polyubiquitinated proteins, which may be fundamental to the function of CTAGE2. Nocodazole disrupts microtubule polymerization, which can lead to cell cycle arrest, again potentially inhibiting CTAGE2. Furthermore, Purvalanol A, a cyclin-dependent kinase inhibitor, halts cell cycle progression, which would impact CTAGE2 function. Lastly, BI 2536, another potent Plk1 inhibitor, can lead to mitotic arrest, which would impede the function of CTAGE2, as the disruption of Plk1 activity would affect mitotic progression and thus the function of CTAGE2 in this process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora kinase A inhibitor. Aurora kinase A is a key regulator of mitosis. Inhibition of this kinase can disrupt the cell cycle, which could impede the function of CTAGE2 if CTAGE2 is involved in mitotic processes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor with activity against both Aurora A and B kinases. By targeting these kinases, the chemical can interfere with cell division, potentially inhibiting CTAGE2 functions associated with this process. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
Volasertib is a Polo-like kinase 1 (Plk1) inhibitor. Plk1 is crucial for mitotic spindle formation. Inhibiting Plk1 can result in mitotic arrest, potentially inhibiting CTAGE2 if it is involved in spindle formation or function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which is necessary for mitosis. This action can inhibit CTAGE2 if the protein's function is related to microtubule dynamics during cell division. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor, which disrupts spindle bipolarity during mitosis. If CTAGE2 is involved in spindle dynamics or structure, its function would be inhibited by such an action. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
This compound is another Eg5 kinesin inhibitor, leading to spindle assembly defects. If CTAGE2 is associated with proper spindle assembly, its function would be inhibited by S-Trityl-L-cysteine. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is another proteasome inhibitor that can lead to the accumulation of proteins destined for degradation. If CTAGE2 function is related to this pathway, inhibition of the proteasome would impede its activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that prevents the degradation of polyubiquitinated proteins. By doing so, it can inhibit CTAGE2 if the protein is involved in pathways requiring proteasome activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. Inhibition of microtubule dynamics can lead to cell cycle arrest, which would inhibit CTAGE2 if the protein is involved in cell cycle progression that relies on microtubules. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is a cyclin-dependent kinase inhibitor. It can inhibit the progression of the cell cycle, and if CTAGE2 is involved in cell cycle regulation, its function would be inhibited by the action of Purvalanol A. | ||||||