Cripto-3 Inhibitors
Cripto-3 inhibitors constitute a specialized class of chemical compounds targeting the Cripto-3 protein, a member of the EGF-Cripto-1/EGF family known for its role in various cellular processes, including embryonic development and cell signaling. Cripto-3 is characterized by its distinctive structure, featuring a single EGF-like domain that facilitates interactions with growth factor receptors, particularly those involved in the modulation of signaling pathways such as the TGF-beta and Wnt pathways. The inhibitors designed to obstruct Cripto-3 function play a crucial role in dissecting the protein's contribution to normal and pathological processes at the cellular level.
The design of Cripto-3 inhibitors often involves a combination of computational modeling and high-throughput screening of chemical libraries to identify promising candidates. Structure-activity relationship (SAR) studies are integral to refining these inhibitors, allowing researchers to understand how modifications in chemical structure can influence their binding affinity and specificity for Cripto-3. Additionally, various in vitro assays are employed to evaluate the inhibitory effects of these compounds on Cripto-3 mediated pathways, providing insights into the mechanistic aspects of how these inhibitors interact with the protein. The ongoing exploration of Cripto-3 inhibitors not only sheds light on the fundamental biological roles of Cripto-3 but also enhances the understanding of broader signaling networks that govern cellular behavior and differentiation. This research serves to deepen the knowledge of the complexities inherent in protein interactions and the regulatory mechanisms that influence developmental and cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By incorporating into DNA where cytosine normally occurs, 5-Azacytidine could lead to the demethylation of the Cripto-3 gene's promoter region, thereby decreasing its transcriptional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A could promote the acetylation of histones near the Cripto-3 gene, potentially leading to a condensed chromatin state and a subsequent reduction in Cripto-3 mRNA synthesis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, through its active metabolite, could bind to retinoic acid receptors that either repress or fail to activate the transcription of the Cripto-3 gene, resulting in diminished expression levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to FKBP12 and together the complex inhibits mTORC1, which could lead to a reduction in transcription factors necessary for Cripto-3 expression or a decrease in the stability of Cripto-3 mRNA. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 competitively inhibits PI3K, potentially leading to the attenuation of the PI3K/Akt signaling cascade and a consequent decrease in the expression levels of Cripto-3. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $214.00 $326.00 $1275.00 | 1 | |
Wnt-C59 inhibits the production of Wnt proteins, which could lead to the disruption of Wnt signaling pathways and thereby the downregulation of Cripto-3, which may be influenced by those pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 inhibits MEK1/2, enzymes within the MAPK/ERK pathway, potentially resulting in decreased activation of transcriptional machinery necessary for Cripto-3 gene expression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK1/2 and could lead to the suppression of ERK phosphorylation, which may be required for the transcriptional activation of the Cripto-3 gene. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT inhibits gamma-secretase, an enzyme necessary for the cleavage of certain membrane proteins. The inhibition could lead to the suppression of signaling pathways that, when active, increase Cripto-3 expression. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 is an inhibitor of ALK5, and by inhibiting this kinase, it could lead to the downregulation of the Smad signaling pathway, potentially resulting in decreased expression of downstream targets like Cripto-3. | ||||||