COUP-TF2 Inhibitors
COUP-TF2 inhibitors are chemical compounds that specifically target and inhibit the activity of COUP-TF2 (Chicken Ovalbumin Upstream Promoter-Transcription Factor 2), a member of the nuclear receptor superfamily of transcription factors. COUP-TF2, also known as NR2F2, plays a critical role in regulating gene expression by binding to specific DNA sequences in target genes, thereby influencing processes such as cell differentiation, organogenesis, and metabolic regulation. It is particularly involved in the development of the cardiovascular system, regulating angiogenesis, and maintaining tissue homeostasis. As a transcription factor, COUP-TF2 can function as both a repressor and activator of gene expression, depending on the cellular context and the interacting co-factors.
Inhibitors of COUP-TF2 function by interfering with its ability to bind to DNA or interact with co-regulators, thus preventing it from exerting its effects on gene transcription. These inhibitors may bind to the ligand-binding domain or the DNA-binding domain of COUP-TF2, thereby obstructing its capacity to modulate gene expression. Through the use of COUP-TF2 inhibitors, researchers can study the precise role of this transcription factor in various developmental and physiological processes. For instance, these inhibitors are valuable tools in exploring how COUP-TF2 regulates angiogenesis and vascular development, as well as its involvement in metabolic pathways. By blocking COUP-TF2 activity, it becomes possible to investigate the downstream genetic networks it controls, providing insights into its broader biological functions, including its role in development, cellular differentiation, and homeostatic regulation across different tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could downregulate COUP-TF2 by binding to retinoic acid receptors, which may then sequester coactivators essential for COUP-TF2 transcriptional activity. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole has the potential to decrease COUP-TF2 expression by inhibiting cytochrome P450 enzymes, leading to reduced steroidogenesis and consequent hormonal imbalances that diminish COUP-TF2 transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could reduce COUP-TF2 expression via histone deacetylase inhibition, resulting in hyperacetylated chromatin that impedes transcription factors from accessing the COUP-TF2 promoter region. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A may inhibit COUP-TF2 expression through its DNA-binding capability, obstructing the binding sites on the COUP-TF2 promoter and preventing transcription initiation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 could attenuate COUP-TF2 expression by blocking PI3K, which is crucial for the activation of downstream transcription factors involved in COUP-TF2 gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine might decrease COUP-TF2 expression by causing DNA demethylation, which could activate genes encoding repressors that specifically target the COUP-TF2 promoter. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid might result in reduced COUP-TF2 expression by inhibiting histone deacetylases, tightening chromatin structure around the COUP-TF2 locus, and thus hindering transcriptional activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram could inhibit the expression of COUP-TF2 by inactivating NF-κB, potentially reducing the transcriptional activation of the COUP-TF2 gene, which may be under partial control of NF-κB. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
4-Hydroxyphenylretinamide may downregulate COUP-TF2 by disrupting retinoid signaling pathways that are necessary for maintaining COUP-TF2 gene expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 could lead to a decrease in COUP-TF2 expression by specifically inhibiting MEK1/2, thereby lowering ERK pathway signaling that can contribute to COUP-TF2 gene transcription. | ||||||