CLS1 Inhibitors
CLS1 inhibitors are a class of chemical compounds that have garnered significant attention in the field of molecular biology and biochemistry. These inhibitors are primarily known for their role in modulating cellular processes related to lipid metabolism and lipid droplet formation. Within the cell, lipids play a crucial role as energy stores and as structural components of membranes. The regulation of lipid metabolism is essential for maintaining cellular homeostasis, and CLS1 inhibitors have emerged as key players in this intricate regulatory network.
CLS1 inhibitors act by targeting an enzyme known as CLS1, which is short for CDP-diacylglycerol synthase 1. This enzyme plays a pivotal role in lipid biosynthesis by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. CDP-diacylglycerol, in turn, serves as a precursor for the synthesis of various lipid molecules, including phospholipids and glycerophospholipids, which are integral components of cell membranes. By inhibiting CLS1, these compounds disrupt the production of CDP-diacylglycerol, leading to alterations in cellular lipid composition. This disruption can have far-reaching effects on cellular functions, including membrane integrity, vesicular trafficking, and lipid droplet formation, which are critical for cellular processes such as energy storage and lipid homeostasis. In summary, CLS1 inhibitors represent a class of chemical compounds with the unique ability to modulate lipid metabolism by targeting the CLS1 enzyme, thereby influencing various aspects of cellular physiology related to lipids and membranes.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
Atrazine can disrupt mitochondrial function, potentially affecting the environment CRLS1 operates within. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits mitochondrial ATP synthase, which might alter cardiolipin synthesis indirectly. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine can integrate into phospholipid layers, potentially altering CRLS1 substrate availability. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine can affect mitochondrial membranes, which may influence CRLS1 activity. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
Cerulenin inhibits fatty acid synthesis, which could reduce the availability of CRLS1 substrates. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide disrupts mitochondrial electron transport, which might affect CRLS1 indirectly. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits mitochondrial complex I, which could alter the mitochondrial environment for CRLS1. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits mitochondrial complex III, potentially affecting CRLS1 indirectly. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $148.00 $496.00 | 3 | |
Etomoxir inhibits carnitine palmitoyltransferase, which could affect lipid metabolism related to CRLS1. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole affects ergosterol synthesis and may indirectly affect phospholipid synthesis pathways. | ||||||