Molecular structure of Antimycin A, CAS Number: 1397-94-0
Antimycin A (CAS 1397-94-0)
See product citations (51)
Alternate Names:
Antipiricullin; Virosin
Application:
Antimycin A is a mitochondrial electron transport inhibitor and antibiotic that induces apoptosis.
CAS Number:
1397-94-0
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Antimycin A is an antibiotic that induces apoptosis and inhibits the mitochondrial electron transport chain from cytochrome b to cytochrome C1. Additionally, studies report that it causes damage to mitochondrial DNA, lipids, and proteins in cells treated with the antibiotic. Antimycin A may act to mimic cell-death-inducing Bcl-2 homology domain 3 and has been applied as a reactive oxygen species (ROS) generator to study biological systems. Research indicates that Antimycin A inhibits the cell growth of HeLa cells though apoptosis and blocks nitric oxide-induced apoptosis via inhibition of cytochrome C leakage.
Antimycin A (CAS 1397-94-0) References
- Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. | Tzung, SP., et al. 2001. Nat Cell Biol. 3: 183-91. PMID: 11175751
- Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A. | Kim, KM., et al. 2001. Biochemistry. 40: 4911-22. PMID: 11305906
- Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage. | Dairaku, N., et al. 2004. J Lab Clin Med. 143: 143-51. PMID: 15007303
- An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis. | Park, WH., et al. 2007. J Cell Biochem. 102: 98-109. PMID: 17372917
- Antimycin A-induced mitochondrial apoptotic cascade is mitigated by phenolic constituents of Phyllanthus amarus aqueous extract in Hep3B cells. | Guha, G., et al. 2010. Food Chem Toxicol. 48: 3449-57. PMID: 20854871
- Antimycin A effect on the electron transport in chloroplasts of two Chlamydomonas reinhardtii strains. | Antal, TK., et al. 2013. Planta. 237: 1241-50. PMID: 23354456
- Pinacidil protects osteoblastic cells against antimycin A-induced oxidative damage. | Choi, EM., et al. 2015. Mol Med Rep. 11: 746-52. PMID: 25334089
- Streptomyces strains producing mitochondriotoxic antimycin A found in cereal grains. | Rasimus-Sahari, S., et al. 2016. Int J Food Microbiol. 218: 78-85. PMID: 26619316
- Antimycin A increases bronchopulmonary C-fiber excitability via protein kinase C alpha. | Bahia, PK., et al. 2020. Respir Physiol Neurobiol. 278: 103446. PMID: 32360368
- Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells. | Korhonen, E., et al. 2021. Exp Eye Res. 209: 108687. PMID: 34216617
- Marine Natural Product Antimycin A Suppresses Wheat Blast Disease Caused by Magnaporthe oryzae Triticum. | Paul, SK., et al. 2022. J Fungi (Basel). 8: PMID: 35736101
- Antimycin A induced apoptosis in HCT-116 colorectal cancer cells through the up- and downregulation of multiple signaling pathways. | Kabir, SR. and Islam, T. 2022. Med Oncol. 40: 51. PMID: 36527492
- High-performance liquid chromatographic resolution and quantification of a dilactonic antibiotic mixture (antimycin A). | Abidi, SL. 1982. J Chromatogr. 234: 187-200. PMID: 7056827
- The respiratory-chain poison antimycin A promotes the formation of DNA single-strand breaks and reduces toxicity in U937 cells exposed to t-butylhydroperoxide. | Guidarelli, A., et al. 1996. Biochem J. 317 (Pt 2): 371-5. PMID: 8713060
Inhibitor of:
1190007I07Rik, 1810026J23Rik, 1810043H04Rik, 2′-PDE, 2900010M23Rik, 4930420K17Rik, 4930443G12Rik, ACAD-9, AI-BP, ALKBH7, Anamorsin, ANT3, apoOL, ASF1A, ATAD3B, ATAD3C, ATP5, ATP5ATP5L2, ATP5C1, ATP5E, ATP5F1, ATP5I, ATP5S, ATP6, ATP8, ATPAF2, ATPIF1, BCS1L, BOLA3, BRP44L, C10orf88, C11orf83, C19orf12, C20orf7, C3orf60, C4orf14, C7orf44, C7orf73, C8orf38, CABC1, CCDC44, CCDC58, CHCHD8, CHPPR, CKMT1A, Clpb, CLS1, COA1, COA5, COX14, COX20, COX6a2, COX7a2L, COX7b2, COX8b, Cstad, CYB5D1, Cyclophilin F, cytochrome b, cytochrome b561, Cytochrome c, Cytochrome c oxidase (COX), cytochrome c1, D10Wsu102e, EF-G2, EG623286, ERAL1, ETFDH, ETHE1, FAHD1, FAM113B, FAM173A, FAM173B, FAM96B, FASTKD2, FASTKD3, FDX1L, FLAD1, GABP-β1, GCDH, GDAP1, GDAP1L1, Grim19, GTPBP3, GTPBP5, GUF1, HCCR-1, HCCS, HDMCP, HIGD1A, HIGD1B, HIGD2A, HRPAP20, HscB, HSP 75, IARS2, IMMP1L, IMMP2L, KIAA1143, LACE1, LACTB2, LIAS, LIPT1, LOC283398, LONP1, LONP2, LRP130, LYCAT, LYRM1, LYRM2, LYRM4, LYRM5, Magmas, MCART2, MCART6, MCEE, MDH1B, ME3, Mecr, Metaxin 3, Mimitin, Mimp, MINOS1, MIPEP, Misato, Mitochondrial Inner Membrane, Mitochondrial Marker, Mitofilin, MMAA, MP68, MPV17, MPV17L2, MRP-L33, MRP-L46, MT-ND (mitochondrial NADH dehydrogenase), MTCH1, Mtch2, MTERF, MTERFD1, MTERFD2, MTG1, MTHFD2L, Mtif3, MTMR12, MTO1, mtp110, MTRF1, mtTFA, NARFL, ND4, ND6, NDH II, NDUFA4L2, NDUFAF7, NDUFB2, NDUFB5, NDUFB6, NDUFB7, NDUFB9, NDUFC1, NDUFC2, NDUFS5, NIMP, NUBPL, Olfr571, Oma1, OPA3, OSAP, OSCP1, OXA1L, P117, p60 Mitochondrial Marker, Paraplegin, PARL, PET100, PINK1, PMPCB, PRELI, PRELID2, PTCD1, PTCD2, PTCD3, PYROXD2, QCR10, QIL1, QP-C, RDH13, Rho T2, RMND1, RPUSD1, RPUSD2, Sam50, SCAF1, SCOCO, SDHAF1, SDHC, SFXN1, SFXN2, SFXN3, SFXN4, SFXN5, SLC25A21, SLC25A22, SLC25A3, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A48, SLC43A3, SMCR7L, SPATA18, SQRDL, Syntaphilin, TAMM41, TaR-1, TBC1D20, TFB1M, TFB2M, Tim13A/B, Tim17A, Tim17B, Tim22, Tim50, TMEM11, TMEM126A, TMEM135, TMEM70, Tom34, Tom40B, Tom7, Tomm5, TTC19, UCRC, uMtCK, UNQ9438, Uqcr, UQCRB, UQCRC1, UQCRC2, UQCRH, UQCRHL, USMG5, WBSCR18, WDR93, XylT-I, Yfh1, YME1L1, and ZCSL3.Activator of:
4930420K17Rik, AFG3L2, ATP5D, Bax, BFZB, C20orf7, C20orf72, ClpP, COX6a2, Cstad, Cyclophilin F, DHRS2, dinitrophenol, FUNDC1, GHITM, JAGN1, KIAA0664, LETM2, MCJ, Mitoferrin 2, MRP-L20, MRP-L22, MRP-L41, MRP-S18B, MRRF, MsrB3, MTFmt, ND1, ND6, NDUFA1, NDUFA10, NDUFAB1, NDUFS6, NDUFV3, OSCP, PISD, Pma1p, PPA2, QCR10, Romo1, RV3134 Dormancy Regulon, SDHAF2, SLC25A18, SLC25A3, SUCLG2, TaR-1, Tim22, Tim23, Tim8B, TMEM60, Tomm20l, TRAP-1, UQCRB, and UQCRHL.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Antimycin A, 5 mg | sc-202467 | 5 mg | $54.00 | |||
Antimycin A, 10 mg | sc-202467A | 10 mg | $62.00 | |||
Antimycin A, 1 g | sc-202467B | 1 g | $1642.00 | |||
Antimycin A, 3 g | sc-202467C | 3 g | $4600.00 |