CLEC-14A Activators
CLEC-14A Activators are a group of chemical compounds that indirectly augment the functional activity of CLEC-14A through various signaling pathways. Forskolin, by elevating intracellular cAMP levels, indirectly enhances CLEC-14A's functional role in cell-cell adhesion by activating PKA, which can phosphorylate substrates involved in this process. Similarly, Genistein, through tyrosine kinase inhibition, allows CLEC-14A pathways to be more active by reducing competition from tyrosine kinase signaling. Sphingosine-1-phosphate and Thapsigargin both work through the modulation of lipid and calcium signaling, respectively, to potentiate the cellular adhesion processes in which CLEC-14A is involved. PMA, as a PKC activator, Epigallocatechin gallate as a kinase inhibitor, and the PI3K inhibitors LY294002 and Wortmannin, all contribute to CLEC-14A activation by either promoting adhesion-related pathways or reducing competitive survival signaling.
The functional activity of CLEC-14A is further influenced by compounds that modulate MAPK signaling, with SB203580 and U0126 inhibiting p38 and MEK1/2, respectively, shifting the signaling equilibrium to favor pathways associated with CLEC-14A. A23187 enhances CLEC-14A's activity by increasing intracellular calcium levels, thus activating calcium-dependent signaling pathways crucial for cell adhesion. Staurosporine, despite being a broad-spectrum protein kinase inhibitor, might lead to the selective activation of CLEC-14A pathways by lifting the inhibition exerted by specific kinases on CLEC-14A-related processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cyclic AMP levels. CLEC-14A is involved in cellular adhesion processes that can be influenced by cAMP-dependent protein kinase A (PKA) signaling. Elevated cAMP levels enhance PKA activity, which can lead to phosphorylation of substrates involved in adhesion, potentially enhancing CLEC-14A-mediated cell-cell interactions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Since CLEC-14A is a C-type lectin receptor, its function could be enhanced through the inhibition of competing tyrosine kinase signaling pathways, thus allowing its pathway to be more active or less repressed in cellular environments where tyrosine kinase activity is high. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) engages S1P receptors leading to various intracellular signaling cascades that can enhance cellular adhesion and migration. Since CLEC-14A is involved in cell-cell adhesion, S1P may enhance its function by potentiating the cellular processes in which CLEC-14A is involved. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can then enhance the function of many proteins involved in cellular adhesion and migration, pathways where CLEC-14A has a functional role. PKC-mediated signal transduction can enhance the functional activity of CLEC-14A by promoting its involvement in cellular adhesion. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels. Elevated calcium may activate calcium-dependent signaling pathways, indirectly enhancing the function of CLEC-14A in calcium-dependent cellular adhesion processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit various protein kinases and has been shown to affect cellular adhesion mechanisms. By inhibiting competitive signaling pathways, EGCG could enhance the functional activity of CLEC-14A in cell-cell adhesion. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor which can alter the AKT signaling pathway. Since CLEC-14A is involved in cellular processes that can be regulated by PI3K/AKT, inhibition of this pathway could enhance specific aspects of CLEC-14A function by favoring adhesion over survival signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, SB203580 could reduce competition for downstream signaling molecules, possibly enhancing signal transduction pathways that promote the function of CLEC-14A in cellular adhesion. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that can suppress AKT signaling. This suppression could enhance CLEC-14A function by reducing signaling through pathways that negatively regulate cellular processes in which CLEC-14A is involved, such as cell adhesion and migration. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. By influencing calcium-dependent signaling pathways, it can enhance the function of CLEC-14A, which is implicated in calcium-dependent cellular adhesion processes. | ||||||