CLAMP Activators
CLAMP Activators comprise a diverse group of chemical compounds that indirectly augment the functional activity of CLAMP, primarily through their interactions with chromatin structure and gene expression regulation. The group includes various HDAC inhibitors such as Trichostatin A, SAHA, Sodium Butyrate, MS-275, Romidepsin, Valproic Acid, and Panobinostat. These inhibitors enhance CLAMP's activity by altering chromatin accessibility and structure, a crucial aspect of CLAMP's role in gene expression regulation. By modifying the chromatin landscape, these compounds facilitate CLAMP's ability to regulate genes effectively, particularly on the X chromosome.
Additionally, DNA methyltransferase inhibitors like 5-Azacytidine, RG108, and Decitabine also play a significant role. They influence CLAMP by altering DNA methylation patterns, which is a key factor in gene expression regulation. JQ1, a BET bromodomain inhibitor, and Mithramycin A, a DNA-binding antibiotic, further contribute to this modulation. They impact chromatin structure and function, thereby influencing CLAMP's activity in chromatin modification and gene expression regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA, an HDAC inhibitor, can enhance CLAMP activity by altering chromatin structure, potentially making it more accessible for CLAMP-mediated regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, could influence CLAMP by altering DNA methylation patterns, thus affecting gene expression regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA, another HDAC inhibitor, could enhance CLAMP's functional activity by modifying chromatin structure and accessibility. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate, an HDAC inhibitor, can affect chromatin structure, potentially enhancing CLAMP's role in chromatin modification and gene expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A, a DNA-binding antibiotic, could influence CLAMP activity by altering the chromatin structure and gene expression patterns. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275, a selective HDAC inhibitor, could enhance CLAMP activity by modulating chromatin accessibility and gene expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108, a DNA methyltransferase inhibitor, could indirectly enhance CLAMP's functional activity by affecting DNA methylation and gene expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1, a BET bromodomain inhibitor, could influence CLAMP by modulating chromatin structure and gene expression, especially on the X chromosome. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin, an HDAC inhibitor, could enhance CLAMP activity by affecting chromatin structure and thus gene expression regulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine, a DNA methyltransferase inhibitor, can influence CLAMP activity by altering DNA methylation patterns, impacting gene expression. | ||||||