CIR Activators
CIR activators include a class of compounds that can modulate epigenetic markers and influence signaling pathways indirectly associated with the transcriptional repression activities of CIR. These activators typically function by altering the acetylation and methylation status of histones, thereby affecting the chromatin state and the transcriptional dynamics of the genes involved in Notch signaling, where CIR acts as a corepressor.
Chemical activators such as HDAC inhibitors, like Valproic Acid, Trichostatin A, and SAHA, can lead to increased histone acetylation, which may reduce the binding affinity of CIR to the chromatin, thus relieating its repressive effects on gene transcription. This modification in the chromatin landscape can facilitate a more transcriptionally permissive environment. Similarly, DNA methyltransferase inhibitors, like 5-Azacytidine, could disrupt CIR's ability to maintain a repressed chromatin state by causing DNA demethylation, thereby enhancing the expression of target genes. On the other hand, small molecules like DAPT, by modulating the cleavage of Notch receptors, may alter the Notch signaling pathway's flux and consequently its interaction with CIR. Compounds like Lithium Chloride can indirectly influence CIR activity by inhibiting GSK-3, increasing beta-catenin levels and affecting the gene regulatory networks associated with Notch signaling.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A histone deacetylase (HDAC) inhibitor that can alter chromatin structure, potentially leading to transcriptional activation of Notch target genes and modulation of CIR activity as the corepressor. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Another HDAC inhibitor that may relax chromatin structure, potentially counteracting CIR-mediated transcriptional repression by allowing for transcriptional activators to access DNA. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can result in DNA demethylation, potentially disrupting the interaction of CIR with chromatin and alleviating its repressive effects on transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An HDAC inhibitor that can lead to hyperacetylation of histones, possibly diminishing the repressive effects of CIR on chromatin and activating transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
By influencing gene expression and differentiation pathways, retinoic acid can modify transcriptional regulation, which may affect CIR activity indirectly. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
An inhibitor of glycogen synthase kinase-3 (GSK-3), which could lead to increased levels of beta-catenin, a molecule that interacts with the Notch pathway and might influence CIR's role in transcriptional repression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As an HDAC inhibitor, it can enhance histone acetylation and may disrupt CIR-mediated repression by altering chromatin accessibility. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
A gamma-secretase inhibitor that blocks Notch receptor cleavage, potentially modulating the downstream effects on corepressors such as CIR by altering pathway flux. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
It has been shown to modulate various signaling pathways, including those that intersect with Notch signaling, which could indirectly affect CIR function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound known to modulate multiple signaling pathways, which may include interactions with pathways that converge on or interact with Notch signaling, potentially affecting CIR activity. | ||||||