Date published: 2025-10-15

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CIR Inhibitors

CIR inhibitors are a group of compounds that focus on modulating the activity or the influence of the Cytoplasmic inhibitor of R7, also known as CIR1. Since direct inhibitors are not extensively documented for this protein, the inhibitors listed above act indirectly by targeting associated pathways or cellular processes. Proteasome inhibitors like MG-132 can impact CIR1 by preventing the degradation of proteins it interacts with or modulating its stability. Similarly, compounds like LY294002 and Wortmannin, which inhibit the phosphatidylinositol 3-kinase (PI3K), can modulate broader cellular processes and pathways that CIR1 might be a part of, given the PI3K's extensive involvement in cell survival, growth, and proliferation. Other inhibitors, like PD98059 and U0126, target the MEK-ERK pathway, affecting cell differentiation, proliferation, and survival. Additionally, broader kinase inhibitors, such as Staurosporine, offer a wide-ranging impact on cellular pathways, including any processes involving CIR1.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

Proteasome inhibitor that can prevent degradation of proteins, possibly affecting CIR1's interactions or stability.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

PI3K inhibitor that can potentially modulate pathways where CIR1 is involved, given the broad roles of PI3K in various cellular processes.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Another PI3K inhibitor that, like LY294002, might modulate cellular processes associated with CIR1.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

Inhibits MEK, an upstream activator of ERK. If CIR1 is involved in ERK pathways, PD98059 can indirectly influence its function.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Broad-spectrum protein kinase inhibitor which can influence multiple pathways and might indirectly modulate CIR1-related processes.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

JNK inhibitor which can impact pathways related to stress responses and apoptosis, potentially intersecting with CIR1 functions.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

ROCK inhibitor that affects pathways related to cytoskeleton dynamics and might indirectly influence processes where CIR1 plays a role.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

Inhibits MEK1 and MEK2, thereby potentially affecting any ERK-related pathways in which CIR1 is involved.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

Inhibits p38 MAPK, affecting pathways related to stress responses and potentially those involving CIR1.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

mTOR inhibitor that affects protein synthesis and cellular growth, potentially influencing CIR1-associated processes.