CH25H Inhibitors
The chemical class known as CH25H inhibitors comprises a group of compounds that are specifically designed to target and inhibit the activity of the cholesterol 25-hydroxylase enzyme, also referred to as CH25H. This enzyme is involved in the metabolism of cholesterol, playing a critical role in converting cholesterol to 25-hydroxycholesterol (25HC). By inhibiting the activity of CH25H, these compounds can potentially interfere with the production of 25HC, which is a biologically active oxysterol. Oxysterols are important signaling molecules that can impact various cellular processes, including immune responses and inflammation. CH25H inhibitors are synthesized to modulate the cholesterol metabolism pathway and consequently affect cellular functions influenced by 25HC.
Researchers have been actively investigating various chemical structures and modifications to develop effective CH25H inhibitors with enhanced specificity and potency. By understanding the interactions between these inhibitors and the enzyme's active site, scientists aim to gain insights into the underlying molecular mechanisms and utilize this knowledge to further explore their potential applications in different research areas.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $53.00 $91.00 $169.00 $474.00 | 8 | |
25-Hydroxycholesterol is an activator of caspases and Bcl-2 expressor | ||||||
Cholesterol 5α,6α-epoxide | 1250-95-9 | sc-214687 | 50 mg | $95.00 | 1 | |
Cholesterol 5α,6α-epoxide is used to study oxysterol-induced toxicity | ||||||
22(R)-hydroxycholesterol | 17954-98-2 | sc-205106 sc-205106A sc-205106B | 1 mg 5 mg 10 mg | $110.00 $357.00 $612.00 | 1 | |
22(R)-hydroxycholesterol is an endogenous LXR agonist | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone is a C-21 steroid hormone involved in uterine endothelium activity | ||||||
5α-Pregnane-3α,20α-diol | 566-58-5 | sc-207076A sc-207076 sc-207076B | 5 mg 10 mg 25 mg | $274.00 $352.00 $699.00 | ||
5α-Pregnane-3α,20α-diol is A progesterone metabolite | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin is a rifamycin antibiotic that potently inhibits RNA polymerase, blocks RNA synthesis, and is an activator of PXR. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $89.00 $224.00 | 5 | |
T 0901317 is a cell-permeable, nonsterol compound that acts as a highly potent LXR activator | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole is a triazole antifungal agent | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole is an inhibitor of CYP proteins, thromboxane synthetase, and 5-LO | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole is an antifungal compound and CYP inhibitor | ||||||