CEM15 Activators
CEM15 Activators are chemical compounds that can enhance the biological functionality of CEM15. Compounds such as Forskolin and Ionomycin elevate intracellular messenger concentrations, namely cAMP and calcium, respectively, which in turn activate downstream kinases like PKA and calcineurin. This cascade of activation leads to phosphorylation events and transcriptional changes that ultimately bolster the functional capacity of CEM15 in mediating intracellular antiviral responses. Similarly, Prostratin's activation of PKC is believed to facilitate the proper cellular localization of CEM15, which is paramount for its effective participation in combating viral infections. Resveratrol, by activating SIRT1, and Curcumin, through NF-κB inhibition, modulate the cellular environment to promote the longevity and activity of cells expressing CEM15, thereby indirectly contributing to its role in the innate immune system.
The action of CEM15 is further refined by the influence of kinase inhibitors like Epigallocatechin gallate(EGCG) and Quercetin, which alleviate negative regulatory controls, allowing CEM15 to exert its antiviral mechanisms more effectively. The autophagy inducer Spermidine, through the inhibition of EP300, and the cell differentiation modulator Retinoic acid, each contribute to enhancing the conditions under which CEM15 operates optimally within immune responses. Additionally, Piperlongumine, by elevating ROS levels, Capsaicin, through TRPV1 mediated calcium influx, and Lithium chloride, via GSK-3 inhibition, each indirectly contribute to an environment that enhances the activity of CEM15.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels within the cell. Elevated cAMP activates protein kinase A (PKA), which can enhance CEM15 activity by phosphorylation, thereby increasing its ability to mediate antiviral responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a deacetylase which can indirectly enhance the activity of CEM15 by modulating the cellular environment and promoting the longevity of cells that express CEM15, thus supporting its role in the innate immune response. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $138.00 $530.00 | 24 | |
Prostratin activates protein kinase C (PKC), which can enhance the functional activity of CEM15 by promoting its appropriate localization within the cell, allowing it to effectively participate in antiviral defense mechanisms. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can lead to the activation of calcineurin and subsequently NFAT, a transcription factor that may enhance the expression of CEM15, enabling it to more effectively exert its function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB, a factor that when overactivated, can suppress the antiviral mechanisms in which CEM15 is involved. By inhibiting NF-κB, curcumin may indirectly enhance the functional activity of CEM15. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that can modulate multiple signaling pathways. By inhibiting certain kinases, EGCG may reduce negative regulatory influences on CEM15, enhancing its antiviral activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin can activate transient receptor potential vanilloid 1 (TRPV1), which leads to a calcium influx. The subsequent signaling cascade can enhance the defense mechanisms against viral pathogens, where CEM15 plays a crucial role. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to inhibit phosphatidylinositol 3-kinases (PI3K), which can lead to a modulation of the Akt signaling pathway, potentially enhancing the activity of CEM15 in its role in viral restriction. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy through inhibition of the acetyltransferase EP300. Autophagy can enhance the degradation of viral components, a biological process in which CEM15 is an important factor. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates cellular differentiation and proliferation. It can enhance the CEM15-mediated antiviral response by promoting the differentiation of cells into types that express higher levels of CEM15. | ||||||