CD3-δ Activators
The class of CD3-δ activators encompasses a diverse array of compounds that intricately modulate T-cell activation by targeting specific signaling pathways. Calcitriol, a biologically active form of vitamin D3, indirectly activates CD3-δ by modulating the vitamin D receptor (VDR). The complex formed between Calcitriol and VDR regulates gene expression, including those involved in T-cell activation pathways. This modulation enhances CD3-δ-related signaling events, contributing to overall T-cell activation. Similarly, Phorbol 12-Myristate 13-Acetate (PMA) stimulates protein kinase C (PKC), indirectly activating CD3-δ by influencing downstream signaling cascades crucial for T-cell activation. This highlights the importance of DAG and its analogs in modulating the T-cell receptor signaling pathway. Phosphatidylcholine (PC), as a component of cell membranes, indirectly activates CD3-δ by influencing lipid raft composition. The stability of lipid rafts is crucial for T-cell receptor signaling, and PC's role in this process enhances CD3-δ-mediated signaling events, promoting T-cell activation.
Diglyceride (DG) serves as a downstream product in the phosphoinositide signaling pathway, indirectly activating CD3-δ. It acts as a precursor to DAG, which activates PKC, thereby influencing CD3-δ-mediated signaling events. Sodium Orthovanadate, an inhibitor of protein tyrosine phosphatases (PTPs), indirectly activates CD3-δ by preventing the dephosphorylation of signaling molecules. This inhibition amplifies T-cell receptor signaling, leading to enhanced CD3-δ-related events and overall T-cell activation. Ficoll, through changes in osmotic pressure, indirectly activates CD3-δ by modulating T-cell activation. The increased viscosity provided by Ficoll influences the physical properties of the cell membrane, affecting T-cell activation. 2-Phorbol 12,13-Dibutyrate (PDBu) stimulates PKC, serving as a structural analog of PMA and influencing downstream signaling pathways involved in T-cell activation. This indirect activation enhances CD3-δ-mediated signaling events, contributing to overall T-cell activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Calcitriol activates CD3-δ indirectly by modulating the vitamin D receptor (VDR). Upon binding to VDR, Calcitriol forms a complex that regulates gene expression, including genes involved in T-cell activation pathways. This modulation enhances CD3-δ-related signaling events and contributes to the overall activation of T cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates CD3-δ indirectly by stimulating protein kinase C (PKC). Through direct activation of PKC, PMA influences downstream signaling cascades involved in T-cell activation. This leads to enhanced CD3-δ-mediated signaling and augments the activation of T cells. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DiC8 activates CD3-δ indirectly by serving as a soluble analog of diacylglycerol (DAG). DiC8 can directly activate PKC, mimicking the DAG-induced activation of PKC in the T-cell receptor signaling pathway. This leads to the enhancement of CD3-δ-related signaling events and contributes to the overall activation of T cells. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate activates CD3-δ indirectly by inhibiting protein tyrosine phosphatases (PTPs). By preventing the dephosphorylation of signaling molecules, it amplifies T-cell receptor signaling. This leads to enhanced CD3-δ-mediated signaling events and contributes to the overall activation of T cells. | ||||||
Ficoll®, Type 70 | 72146-89-5 | sc-257529 sc-257529A | 5 g 25 g | $47.00 $161.00 | ||
Ficoll activates CD3-δ indirectly by influencing T-cell activation through changes in osmotic pressure. By providing a medium with increased viscosity, Ficoll modulates the physical properties of the cell membrane, affecting T-cell activation. This indirectly enhances CD3-δ-related signaling events and contributes to the overall activation of T cells. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB activates CD3-δ indirectly by modulating calcium signaling. As a calcium channel modulator, 2-APB influences intracellular calcium levels, impacting T-cell activation. This indirectly enhances CD3-δ-mediated signaling events and contributes to the overall activation of T cells. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP activates CD3-δ indirectly by modulating the cAMP-PKA signaling pathway. By serving as a cell-permeable analog of cAMP, db-cAMP activates PKA, influencing downstream signaling cascades involved in T-cell activation. This leads to enhanced CD3-δ-related signaling events and contributes to the overall activation of T cells. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
PDBu activates CD3-δ indirectly by stimulating PKC. As a structural analog of PMA, PDBu activates PKC and influences downstream signaling pathways involved in T-cell activation. This indirectly enhances CD3-δ-mediated signaling events and contributes to the overall activation of T cells. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 Inhibitor IX (6-BIO) activates CD3-δ indirectly by modulating the Wnt/β-catenin signaling pathway. By inhibiting glycogen synthase kinase-3 (GSK-3), it stabilizes β-catenin and influences downstream events involved in T-cell activation. This indirectly enhances CD3-δ-related signaling events and contributes to the overall activation of T cells. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates CD3-δ indirectly by modulating the cAMP-PKA signaling pathway. Through activation of adenylyl cyclase, Forskolin increases cAMP levels, influencing downstream signaling cascades involved in T-cell activation. This leads to enhanced CD3-δ-mediated signaling events and contributes to the overall activation of T cells. | ||||||